| 成娟,陈宏,门剑龙.抗核小体抗体与系统性红斑狼疮的致病相关性[J].安徽医药,2019,23(1):83-86. |
| 抗核小体抗体与系统性红斑狼疮的致病相关性 |
| The relevance of pathogenic between anti-nucleosome antibody and systemic lupus erythematosus |
| 投稿时间：2017-08-13 |
| DOI： |
| 中文关键词: 红斑狼疮,系统性 抗体,抗核 抗体,抗中性白细胞胞质 抗体,抗磷脂 抗U1小核核糖核蛋白抗体 |
| 英文关键词: Lupus erythematosus,systemic Antibodies,antinuclear Antibodies,antineutrophil cytoplasmic Antibodies,antiphospholipid Anti-U1RNP antibody |
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| 中文摘要: |
| 目的 分析抗核小体抗体(anti-nucleosome antibody,AnuA)与系统性红斑狼疮(systemic lupus erythematosus,SLE)的临床表现和其他自身抗体的关系,并了解其与SLE活动性的关系,探讨AnuA在SLE发病中的意义。方法 回顾性分析2014年3月至2016年1月天津医科大学总医院165例SLE住院病人病历资料,其中AnuA阳性者96例,分析其主要的实验室指标与临床特征,并与69例同期住院的AnuA阴性病人比较。结果 AnuA阳性病人抗核抗体、抗双链DNA抗体、抗Sm抗体、抗SSA抗体、抗SSB抗体、抗U1核糖核蛋白抗体阳性率高,更易出现C3及C4下降,发热、皮疹、口腔溃疡、关节炎、肾损害、浆膜炎、光敏感、血小板减少阳性率较高,均差异有统计学意义(χ2值分别为4.187、5.667、4.708、6.660、5.686、12.062、6.793、7.323、4.850、12.617、5.251、6.178、4.850、4.521、7.446、4.377,均P<0.05),两组SLEDAI积分比较差异有统计学意义(t=2.19,P<0.05),两组病人在抗核糖体P蛋白、抗心磷脂抗体、雷诺现象、心包炎、胸膜炎、脱发、神经系统损害、白细胞减少、淋巴细胞减少均差异无统计学意义(P>0.05)。结论 AnuA与抗核抗体、抗双链DNA抗体、抗Sm抗体、抗SSA抗体、抗SSB抗体、抗U1核糖核蛋白抗体高阳性率、C3下降、C4下降、发热、皮疹、口腔溃疡、关节炎、肾损害、浆膜炎、光敏感、血小板减少相关,AnuA与SLE活动性相关,AnuA在SLE的发病中有重要意义。 |
| 英文摘要: |
| Objective To explore the relationship between anti-nucleosome antibody(AnuA),clinical manifestations and laboratory parameters in patients with systemic lupus erythematosus (SLE),and,to investigate AnuA significance in the pathogenesis of SLE.Methods 165 patients from Tianjin Medical University General Hospital from March 2014 to January 2016 in SLE were reviewed,including 96 cases positive AnuA in SLE.AnalyzeThe main laboratory parameters and clinical manifestations were analyzed,and compared with 69 cases negative AnuA in the same period in hospital.Results The positive rate of ANA,anti-dsDNA antibodies,anti-Sm antibodies,anti-SSA antibo dies,anti-SSB antibodies,anti-U1RNP antibodies were significantly higher in negative AnuA patients.and C3 and C4 weredecreased,with statistically significant differences (χ2values were 4.187,5.667,4.708,6.660,5.686,12.062,6.793,7.323,P<0.05),moreover.There were statistical significances in SLEDAI (t=2.19,P<0.05).The incidence of fever,rash,oral ulcers,arthritis,kidney damage,serositis,photosensitivity and thrombocytopenia in positive AnuA patients were significantly higher than those in control group(χ2values were 4.850,12.617,5.251,6.178,4.850,4.521,7.446,4.377,P<0.05).There were all no statistical significances in anti-ribosomal Pprotein,anti-cardiolipin antibodies,Raynaud's phenomenon,pericarditis,pleurisy,alopecia,nervous system damage,leukopenia and lymphopenia (P>0.05).Conclusions AnuA is one of the most valuable marker in diagnosis of SLE.AnuA is closely relevant to ANA,anti-dsDNA antibodies,anti-Sm antibodies,anti-SSA antibodies,anti-SSB antibodies,anti-U1RNP antibodies,C3 and C4 decrease,fever,rash,oral ulcers,arthritis,kidney damage,serositis,photosensitivity and thrombocytopenia in SLE.AnuA is correlated with the activity of SLE,which play an important role in the pathogenesis of SLE. |
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