| 潘莉,朱敏,邰建飞.支原体肺炎患儿血清白细胞介素-4，白细胞介素-17， 干扰素-γ，白细胞介素-36的表达及临床意义[J].安徽医药,2019,23(1):132-135. |
| 支原体肺炎患儿血清白细胞介素-4，白细胞介素-17， 干扰素-γ，白细胞介素-36的表达及临床意义 |
| Serum levelsand clinical significance of IL-4,IL-17,INF-γ and IL-36 in children with mycoplasma pneumoniae pneumonia |
| 投稿时间：2017-02-24 |
| DOI： |
| 中文关键词: 肺炎,支原体 白细胞介素4 白细胞介素17 白细胞介素36 干扰素γ 儿童 |
| 英文关键词: Pneumonia,mycoplasma Interleukin-4 Interleukin-17 Interleukin-36 Interferon-gamma Child |
| 基金项目: |
|
| 摘要点击次数: 1981 |
| 全文下载次数: 667 |
| 中文摘要: |
| 目的 探讨支原体肺炎(MPP)患儿血清细胞因子白细胞介素-4(IL-4),白细胞介素-17(IL-17),干扰素-γ(INF-γ),白细胞介素-36(IL-36)的表达及其临床意义。方法 选择2011年11月1日至2015年11月1日在常州市金坛区人民医院住院的45例确诊为MPP患儿作为MPP组,并选择同期住院的19例行腹股沟疝手术患儿作为对照组进行前瞻性研究。支原体的诊断主要依据痰支原体DNA阳性及血清学指标。采用酶联免疫吸附测定法(ELISA) 检测患儿血清中的IL-4、IL-17、IL-36、INF-γ的含量及变化。结果 MPP组血清IL-4、IL-17、IL-36及INF-γ水平在急性期为:[(723±263)、(398±218)、(413±291)、(3 144±1 932)] ng/L；而对照组为:[(481±198)、(212±39)、(302±87)、(1 632±917)] ng/L,可见MPP组较对照组均明显增高(均P<0.05),在恢复期下降,且大叶性肺炎,>3岁年龄组MPP患儿这四个细胞因子水平均明显增高(均P<0.05)。结论 MPP发生发展与IL-4、IL-17、IL-36及INF-γ密切相关,故检测这些细胞因子对病情评估有一定指导意义,有助于进一步指导MPP的临床治疗。 |
| 英文摘要: |
| Objective To explore the serum levels and clinical significance of interleukin-4 (IL-4),interleukin-17 (IL-17),interferon-γ (INF-γ) and interleukin-36 (IL-36) in children with mycoplasma pneumoniae pneumonia (MPP).Methods In the prospective study,serum levels of IL-4,IL-17,INF-γ and IL-36 were detected by enzyme-linked immunosorbent assay (ELISA) in 45 MPP patients hospitalized in Jintan District People's Hospital of Changzhou from November 2011 to November 2015.At the same time,serum levels of these cytokines of 19 controls hospitalized for surgery were also tested as controls.Diagnosis of mycoplasma pneumoniae was based on both DNA-PCR and serology.Results In acute stage,serum levels of IL-4,IL-17,IL-36 and INF-γ were (723±263),(398±218),(413±291),(3 144±1 932) ng/L in MPP patients,but in the control group were (481±198),(212±39),(302±87),(1632±917) ng/L.So in acute stage,serum levels of IL-4,IL-17,INF-γ and IL-36 were higher in MPP patients and decreased in the convalescence stage (P<0.05).Moreover,patients diagnosed as lobar pneumonia,and aged >3 years had higher levels of these cytokines.Conclusions IL-4,IL-17,INF-γ and IL-36 are involved in the development of MPP and have great clinical significance of disease evaluation. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
