| 苏远婷,项倩彤,张慧.不同浓度过氧苯甲酰凝胶治疗寻常型痤疮的疗效观察[J].安徽医药,2019,23(2):351-353. |
| 不同浓度过氧苯甲酰凝胶治疗寻常型痤疮的疗效观察 |
| Clinical effect of benzoyl peroxide gel with different concentrations on acne vulgaris |
| 投稿时间：2017-06-27 |
| DOI： |
| 中文关键词: 痤疮 过氧苯甲酰凝胶 临床疗效 不良反应 |
| 英文关键词: Acne vulgaris Benzoyl peroxide gel Clinical efficacy Adverse event |
| 基金项目: |
|
| 摘要点击次数: 2005 |
| 全文下载次数: 478 |
| 中文摘要: |
| 目的 观察浓度为2.5%、5%的过氧苯甲酰(BPO)凝胶治疗寻常型痤疮的疗效和安全性。方法 依据随机数字表法、双盲和安慰剂对照的实验方法,将2016年6—12月合肥市第二人民医院皮肤科就诊的120例寻常型痤疮病人分为三组,每组40例,分别外用2.5%、5%的BPO和安慰剂尿素维E乳膏,每晚一次,持续12周。通过治疗前后炎性和非炎性皮疹的计数评估药物的疗效,观察病人的不良反应和局部皮损耐受性。结论 共有113例病人完成此研究,与治疗前炎性损害总数相比,2.5%和5%BPO组分别减少67%和79%,显著高于安慰剂组的46%,三组非炎性皮损数下降各为61%、70%和36%。治疗组出现轻中度刺激性皮损,分别为37.8%和43.2%,两组间差异无统计学意义(P＞0.05),且病人可耐受。结果 浓度为2.5%和5%的BPO治疗寻常型痤疮疗效相同且副作用可耐受,病人依从性高。 |
| 英文摘要: |
| Objective To assess the efficacy and safety of 2.5%,5% benzoyl peroxide (BPO) gel in treating the patients with acne vulgaris.Methods A placebo-controlled,randomized,double-blind study was conducted to assign all 120 patients with acne vulgaris who were treated in The Second People's Hospital from June to December 2016 into 3 groups,with 40 cases in each group.The patients were applied with 2.5% BPO,5% BPO and placebo urea and vitamin Ecream,respectively,once every night for a continuous 12 weeks.Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions before and after the treatment.And safety was evaluated based on adverse events and local skin tolerability scores.Results Totally 113 subjects were included in the full analysis set.In comparison with the inflammatory lesion counts before the treatment,there was a decrease of 67% and 79% respectively in 2.5% BPO group and 5% BPO group,which were significantly higher than those in the placebo group (46%).And the non-inflammatory lesion counts decreased by 61%,70% and 36%,respectively in the three groups.Mild or moderate irritant lesions were found in 2.5% BPO group and 5% BPO group,which were 37.8% and 43.2%,respectively.There was no statistically significant difference between the two groups (P＞0.05),and the patients could tolerate.Conclusions The results suggested that both 2.5% and 5% BPO is equally effective in the treatment of acne vulgaris with tolerated side effects and good patient compliance. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
