| 江海丽,王明琦,张梅,等.加味半夏泻心汤联合亮菌混合液保留灌肠治疗伊立替康肠黏膜损伤的疗效观察[J].安徽医药,2019,23(4):805-808. |
| 加味半夏泻心汤联合亮菌混合液保留灌肠治疗伊立替康肠黏膜损伤的疗效观察 |
| Curative effect of Jiawei banxia xiexin soup combined with armillariella tabescens mixed liquor on irinotecan-induced intestinal mucosal injury |
| 投稿时间：2018-07-03 |
| DOI： |
| 中文关键词: 灌肠 半夏泻心汤 亮菌混合液 伊立替康 肠黏膜损伤 |
| 英文关键词: Enema Banxia xiexin decoction Armillariella tabescens mixed liquor Irinotecan Intestinal mucosal injury |
| 基金项目:国家自然科学基金面上项目(81774051) ◇药物与临床◇加味半夏泻心汤联合亮菌混合液保留灌肠治疗 伊立替康肠黏膜损伤的疗效观察江海丽,王明琦,张梅,李平 (安徽医科大学第一附属医院中西医结合肿瘤科,安徽 合肥 230022) |
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| 中文摘要: |
| 目的 观察加味半夏泻心汤联合亮菌混合液保留灌肠治疗伊立替康(CPT-11)肠黏膜损伤的临床疗效。方法 将2016年10月至2018年5月安徽医科大学第一附属医院及安徽省立医院收治的接受过CPT-11单药或联合方案化疗,并出现急性或迟发性腹泻的病人40例,按照随机数字表法随机分为两组,治疗组(20例)和对照组(20例),治疗组采用加味半夏泻心汤联合亮菌混合液保留灌肠治疗,对照组采用亮菌混合液保留灌肠治疗,2周为一疗程,2周后分别观察两组病人的总有效率、症状和体征、生活质量及不良反应等。结果 治疗组和对照组的总有效率分别为90%和70%,两组比较差异有统计学意义(χ2=9.668,P=0.022)；治疗后治疗组的腹痛及大便性状改变均较对照组下降明显,分别P=0.039, P=0.029,治疗组优于对照组；经治疗后,治疗组卡氏评分提升较对照组大(两组卡氏评分均数的方差分析:F=6.066,P=0.018)；两组在治疗过程中均未见明显不良反应。结论 加味半夏泻心汤联合亮菌混合液保留灌肠治疗CPT-11肠黏膜损伤疗效优于单纯亮菌混合液灌肠。 |
| 英文摘要: |
| Objective To observe the curative effect of Jiawei banxia xiexin soup combined with armillariella tabescens mixed liquor on irinotecan (CPT-11)-induced intestinal mucosal injury.Methods Forty patients of acute or delayed diarrhea caused by CPT-11 single or combined chemotherapy who were treated in The First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital from October 2016 to May 2018 were randomly assigned into the observation group (n=20) and the control group (n=20) according to the random number table method.Patients of the observation group were treated by Jiawei banxia xiexin soup combined with armillariella tabescens mixed liquor,while patients of the control group were treated by armillariella tabescens mixed liquor.After a course of two-week treatment,the total effective rate,symptoms and signs,quality of life and adverse reactions of the two groups were observed.Results The total effective rates had significant differences between the observation group and the control group (90% vs. 70%;χ2=9.668,P=0.022).The symptom scores of abdominal pain and excrement character changing were decreased more significantly in the observation group (P=0.039,P=0.029,respectively),which indicated that the observation group was better than the control group.Karnofsky performance scoring (KPS) in the observation group was increased more significantly than that in the control group (KPS variance analysis result:F=6.066,P=0.018).There were no obvious adverse reactions in neither of the two groups during the treatment course.ConclusionJiawei banxia xiexin soup combined with armillariella tabescens mixed liquor was better than single use of armillariella tabescens mixed liquor in the treatment of irinotecan-induced intestinal mucosal injury. |
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