| 潘笑悦.舌下特异性免疫治疗对合并变应性鼻炎病儿原发性肾病综合征复发率的影响[J].安徽医药,2020,24(1):160-163. |
| 舌下特异性免疫治疗对合并变应性鼻炎病儿原发性肾病综合征复发率的影响 |
| Effects of sublingual immunotherapy on recurrence rate of primary nephrotic syndrome in children patients with allergic rhinitis |
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| DOI：10.3969/j.issn.1009?6469.2020.01.041 |
| 中文关键词: 肾病综合征 鼻炎 脱敏法，免疫 鼻灌洗 复发 免疫球蛋白亚类 蛋白尿 嗜酸细胞 |
| 英文关键词: Nephrotic syndrome Rhinitis Desensitization,immune Nasal lavage Recurrence Immunoglobulin sub? units Proteinuria Eosinophil |
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| 摘要点击次数: 1981 |
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| 中文摘要: |
| 目的探讨舌下特异性免疫治疗( SLIT)对合并变应性鼻炎( AR)病儿原发性肾病综合征( PNS)复发率的影响。方法将河南科技大学第一附属医院 2014年 1月至 2017年 1月收治的 194例合并 AR的 PNS病儿采用随机数字表法分为联合组和常规组，各 97例，常规组接受常规治疗，联合组在常规治疗的基础上加用 SLIT治疗，均治疗 12个月，比较两组临床疗效、 PNS复发率和治疗前后鼻症状总分表( TNSS)评分、免疫球蛋白 E(IgE)、免疫球蛋白 G(IgG)、 24h尿蛋白、生活质量及鼻腔灌洗液炎症因子和鼻分泌物嗜酸性粒细胞( EOS)计数的变化。结果治疗后，两组 TNSS评分均明显降低，联合组 TNSS评分低于常规组［(2.15±0.69)比( 7.94±2.55)分，(3.47±1.12)比( 8.06±2.61)分， P＜0.05］总有效率( 98.97%)高于常规组( 89.69%)(P＜0.05)；两组 IgE［(131.18±42.99)比( 549.53±134.07)U/mL，(219.75±70.24)比(530.，25±129.32)U/mL］、 24h尿蛋白［( 0.85±0.27)比( 4.77± 1.54)g/24 h，(1.31±0.43)比( 4.56±1.43)g/24 h］均明显降低( P＜0.05)IgG［( 16.73±2.55)比( 14.52±1.24)g/L，(15.68±2.04)比(14.31±1.23)g/L］均明显升高( P＜0.05)，联合组 IgE、IgG、24h尿蛋白变化，幅度大于常规组， PNS复发率( 9.29%)均低于常规组(28.87%)(P＜0.05)；两组鼻腔灌洗液 IL?4［(47.75±15.41)比( 82.95±26.76)pg/mL，(62.07±19.63)比( 81.68±26.69)pg/mL］、 IL?17［( 28.34±9.07)比( 41.16±13.28)pg/mL，(34.87±11.24)比( 40.72±13.13)pg/mL］水平和鼻分泌物 EOS计数［( 23.75±7.46)比(64.97±20.33)×103cell/mL，(35.24±11.05)比( 63.81±19.94)×103cell/mL］均明显降低( P＜0.05)但联合组降低幅度大于常规组(P＜0.05)；两组病儿 PedsQLTM4.0各维度评分均明显升高( P＜0.05)，联合组升高幅度大于组( P＜0.05)。结论常规治常规，疗的基础上加用 SLIT治疗合并 AR的 PNS病儿疗效确切，能有效改善病儿鼻炎症状，降低 PNS复发率，提高病儿生活质量。 |
| 英文摘要: |
| Objective To explore the effects of sublingual immunotherapy(SLIT)on the recurrence rate of primary nephrotic syn? drome(PNS)in children patients with allergic rhinitis(AR).Methods Form January 2014 to January 2017.194 cases of childrenpatients with AR and PNS admitted to the First Affiliated Hospital of Henan University of Science and Technology were divided in?to combined group and routine group according to the random number table method，with 97 cases in each group.Routine group was given routine treatment，and combined group was treated with SLIT on the basis of routine treatment，and all patients were treated for 12 months.Clinical efficacy，PNS recurrence rate，total nasal symptom score(TNSS)，immunoglobulin E(IgE)，immunoglobulinG(IgG)， 24h urinary protein，quality of life，and nasal lavage fluid inflammatory factors and nasal secretion eosinophil(EOS) count before and after treatment were compared between the two groups.Results After treatment，the TNSS score was significantlydecreased in the two groups.The TNSS score in combined group was lower than that in routine group［(2.15±0.69)vs.(7.94±2.55) points，(3.47±1.12)vs.(8.06±2.61)points，P＜0.05］，and the total effective rate was higher than that in routine group(98.97% vs. 89.69%)( P＜0.05).The levels of IgE［(131.18±42.99)vs.(549.53±134.07)U/mL，(219.75±70.24)vs.(530.25±129.32)U/mL］ and 24h urinary protein［( 0.85±0.27)vs.(4.77±1.54)g/24h，(1.31±0.43)vs.(4.56±1.43)g/24h］were significantly decreased in the two groups(P＜0.05)while the level of IgG［( 16.73±2.55)vs.(14.52±1.24)g/L，(15.68±2.04)vs. s(14.31±1.23)g/L］was significantly increased(P＜0.05)，and the changes of IgE，IgG and 24h urinary protein in combined group were significant than those in routine group，and the PNS recurrence rate was lower than that in routine group(9.29% vs. 28.87%)( P＜0.05).The lev? els of nasal lavage fluid IL?4［(47.75±15.41)vs.(82.95±26.76)pg/mL，(62.07±19.63)vs.(81.68±26.69)pg/mL］，IL?17［(28.34± 9.07)vs.(41.16±13.28)pg/mL，(34.87±11.24)vs.(40.72±13.13)pg/mL］and nasal secretion EOS count［( 23.75±7.46)vs.(64.97±20.33)×103cell/mL，(35.24±11.05)vs.(63.81±19.94)×103cell/mL］were significantly decreased in the two groups(P＜ |
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