| 陈秀秉,韦月辉,钟健,等.文拉法辛与黛力新治疗功能性胃肠病伴焦虑障碍的疗效对比[J].安徽医药,2020,24(1):174-178. |
| 文拉法辛与黛力新治疗功能性胃肠病伴焦虑障碍的疗效对比 |
| Comparison of the efficacy of venlafaxine and Deanxit in treating functional gastrointestinal disorder with anxiety |
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| DOI：10.3969/j.issn.1009?6469.2020.01.045 |
| 中文关键词: 胃肠疾病 消化不良 抑郁症 文拉法辛 疏肝解郁药 胃食管反流 便秘 功能性胃肠病 焦虑 黛力新 |
| 英文关键词: Gastrointestinal diseases Dyspepsia Depressive disorde Venlafaxine Depressed liver relieving drugs Gas? troesophageal reflux Constipation Functional gastrointestinal disorders Anxiety Deanxit |
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| 中文摘要: |
| 目的分析比较文拉法辛及黛力新对功能性胃肠病( FGIDs)伴焦虑抑郁障碍患者的临床疗效。方法选取 2017年 3月至 2018年 1月在广西钦州市第一人民医院收治的 FGIDs病人 218例。采用随机数字表法分为文拉法辛组( 108例)与黛力新组(110例)文拉法辛组有 7例失访，有 1例治疗 2周后坚决要求停药而终止治疗，实际纳入研究为 100例；而黛力新组有 8例失访，有 2例因，未遵嘱服药而移出研究，故实际纳入研究为 100例。两组均予以抑酸、促动力等常规治疗，在此基础上，文拉法辛组加服文拉法辛治疗，黛力新组加服黛力新治疗，疗程为 24周。第 0、第 1、第 2、第 4、第 8、第 24周对两组进行消化道症状评分(GSRS评分)、汉密尔顿焦虑量表( HAMA)评分以及 SAS焦虑量表评分；根据 SAS评分对两组病人进行焦虑程度分级(分为重度、中度以及轻度)比较第 0周、第 24周两组重度、中度以及轻度焦虑 FGIDs病人 GSRS评分；比较第 0周、第 24周两组各类型 FGIDs病人 GSRS评分，。结果治疗后两组病人的 GSRS、HAMA、SAS评分较治疗前均明显下降( P＜0.001)。治疗 24周后，文拉法辛组功能性便秘病人的 GSRS评分显著低于黛力新组［(0.94±1.18)比( 3.52±3.22)F＝7.756，P＝0.009］胃食管反流病人的 GSRS评分显著低于黛力新组［(0.62±0.50)比( 4.35±3.14)，F＝22.680，P＜0.001］；文拉，法辛组重度焦虑病人，GSRS评分显著低于黛力新组［(1.75±2.26)比( 5.50±2.99)t＝6.003，P＝0.000］中度焦虑病人 GSRS评分显著低于黛力新组［(0.83±0.91)比(2.43±2.47)t＝3.604， 组病人不良反应率( 78.00%)显著高于黛力新组( 49.00%)，差异有统计学意P＝0.000］。文拉法辛，发生，义( P＜0.001)。，结论对伴有焦虑障碍的 FGIDs病人，黛力新和文拉法辛均能明显改善病人消化道症状，有效缓解焦虑障碍，但文拉法辛对中重度焦虑的 FGIDs病人以及胃食管反流、功能性便秘病人的疗效更好。 |
| 英文摘要: |
| Objective To compare the efficacy of venlafaxine and Deanxit in treating functional gastrointestinal disorders(FGIDs) with anxiety.Methods A total of 218 patients with FGIDs in the First People’s Hospital of Qinzhou from March 2017 to January 2018 were selected and randomly divided into venlafaxine group(108 cases)and Deanxit group(110 cases).Seven patients were lost to follow?up，and 1 patient was resolutely requested to discontinue treatment after 2 weeks of treatment in the venlafaxine group，Venlafaxine group included 100 patients actually.8 patients were lost to follow?up，and 2 patients were removed from the study because they did not follow doctor’s advice on the medication in the Deanxit group.Therefore 100 cases was included in the Deanxit group ultimately.All patients were given conventional treatment such as acid suppression and kinetic stimulation.The venla?faxine group was additionally treated with venlafaxine.The Deanxit group was additionally treated with Deanxit.The treatment course is 24 weeks.Gastrointestinal symptoms and anxiety of patients in the two groups were evaluated by Gastrointestinal Symptom RatingScale(GSRS scores)Hamilton Anxiety Scale(HAMA scores)，and Self?Rating Anxiety Scale(SAS scores)at 0，1，2，4，8，and 24 weeks.The anxiety level(，severe，moderate，and mild)of the two groups was graded according to the SAS scores，and then the GSRS scores of FGIDs patients with different levels of anxiety(severe，moderate，mild anxiety)at 0 week and 24 weeks were comparedbetween the two groups.GSRS scores for various types of FGIDs patients at 24th week were compared between the two groups.Results After treatment，GSRS scores significantly decreased in both groups(P＜0.001).After 24 weeks of therapy，the GSRS scores of patients with functional constipation were significantly lower in the venlafaxine group than those in the Deanxit group |
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