| 李祥.2型糖尿病病人甲状腺相关激素水平与冠心病的关联分析[J].安徽医药,2020,24(2):363-366. |
| 2型糖尿病病人甲状腺相关激素水平与冠心病的关联分析 |
| The association of coronary heart disease and the value of the thyroid related hormones of type 2 diabetic patients |
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| DOI：10.3969/j.issn.1009?6469.2020.02.039 |
| 中文关键词: 糖尿病， 2型 冠心病 促甲状腺素 三碘甲状腺原氨酸 胆固醇， LDL 高血压 因果律 |
| 英文关键词: Diabetes mellitus,type 2 Coronary disease Thyrotropin Triiodothyronine Cholesterol,LDL Hypertension Causality |
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| 中文摘要: |
| 目的探讨 2型糖尿病病人甲状腺相关激素水平与冠心病之间的关联。方法选取 2016年 3月至 2018年 6月滁州市中西医结合医院糖尿病病人 360例，分为冠心病组 80例，非冠心病组 280例，测量两组病人血清甲状腺激素水平及其他生化指标含量，使用 logistic回归分析两组病人血清甲状腺相关激素水平与冠心病发生的关系，并使用多元线性回归分析 2型糖尿病病人冠脉病变程度的可能影响因素。结果在年龄、性别均衡可比的情况下，冠心病组病人血清促甲状腺激素( TSH)水平为(3.80±1.63)ng/L，高于非冠心病组的( 1.91±0.67)ng/L，而血清游离三碘甲状腺原氨酸( FT3)水平小于非冠心病组( 3.79±0.49)pg/L比 4.19±0.43)pg/L。logistic回归分析结果显示:血清 TSH水平较高的病人发生冠心病的 OR值为 2.02(1.38~2.97)，而 FT3水平较低的病人发生冠心病的 OR值为 1.32(1.15~1.71)。多元线性回归结果显示高血压、 TSH、低密度脂蛋白胆固醇(LDL?C)水平为冠心病病人冠脉狭窄程度的独立影响因素( P＜0.05)。结论 2型糖尿病病人血清 TSH、FT3水平与冠心病发病风险之间存在关联，同时 TSH也与冠心病病人冠脉病变程度有关。 |
| 英文摘要: |
| Objective To explore the association of coronary heart disease(CHD)and the value of the thyroid related hormones of type 2 diabetic patients.Methods 360 diabetic patients of a department of endocrinology in one hospital were selected as study subjects，235 patients were male and 125 were female.The average ages of the patients were(64.5±10.3)years old.A total of 80cases of CHD were recruited in our study.And 280 cases were free of CHD.The serum levels of thyroid related hormones and otherbiochemical indexes of patients were measured.The independent association between the serum thyroid related hormones and risk ofCHD was analyzed by logistic regression，and the possible influencing factors of the degree of coronary artery lesions were analyzed by multiple linear regression.Results There was no significant difference in characteristics of age and gender between CHD andcontrol group.The level of serum TSH in the CHD group was(3.80±1.63)ng/L，which was significantly higher than that in the con? trol group(1.91±0.67)ng/L.But the level of serum FT3 was lower than the control group(3.79±0.49 vs. 4.19±0.43)pg/L.The binary logistic regression analysis indicated that the OR of the risk of CHD was 2.02(1.38?2.97)and 1.32(1.15?1.71)for patients with high?er level of serum TSH and lower serum FT3.The results of multiple linear regression analysis show that the high blood pressure，se? rum TSH and LDL?C level were the independence influencing factors for the degree of coronary artery lesions(P＜0.05).Conclu? sion The levels of serum TSH，FT3 was associated with CHD of type 2 diabetes mellitus. |
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