| 陈静锋,陈海燕,陈雪梅,等.奥曲肽不同给药方式治疗急性胰腺炎临床效果 Meta分析[J].安徽医药,2020,24(2):402-408. |
| 奥曲肽不同给药方式治疗急性胰腺炎临床效果 Meta分析 |
| Meta?analysis of the clinical effect of octreotide in different administration on acute pancreatitis |
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| DOI：10.3969/j.issn.1009?6469.2020.02.049 |
| 中文关键词: 胰腺炎 输注泵 输注，静脉内 奥曲肽 Meta分析 |
| 英文关键词: Pancreatitis Infusion pumps Infusions,intravenous Octreotide Meta analysis |
| 基金项目: |
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| 中文摘要: |
| 目的采用 Meta分析方法对奥曲肽静脉不同给药方式治疗胰腺炎的有效性进行评价，以期为急性胰腺炎病人奥曲肽给药方式的选择提供依据。方法计算机检索 PubMed、Embase、Cochrane Library、美国 ClinicalTrials数据库、 ScienceDirect、中国期刊全文数据库( CNKI)、中国生物医学文献数据库( CBM)和万方数据库，搜集有关奥曲肽静脉不同给药方式对急性胰腺炎治疗效果的随机对照试验。采用 RevMan 5.3.5软件进行 Meta分析。结果纳入 16篇随机对照试验( RCT)，共 1 266例病人。 Meta分析结果显示，急性胰腺炎病人采用微量输液泵静脉滴注奥曲肽与直接静脉滴注奥曲肽两组给药方式相比，治疗总有效率［RR＝3.14，95%CI(2.09，4.72)P＜0.000 01］显著改善，症状消失时间［MD＝-1.53，95%CI(-1.71，-1.35)P＜0.000 01］、血淀粉酶恢复时间［MD＝-2.83，95%，CI(-3.04，-2.62)P＜0.000 01］、进食恢复时间［MD＝-2.30，95%CI(-2.，62，-1.98)P＜ 0.000 01］、腹痛症状改善时间［MD＝-1.51，95%C.78，-1.25)P＜0.000 01］以及住院时间［MD＝-3.56，95%CI(-32，I(-1，.8，-3.30)，P＜0.000 01］明显缩短，不良反应发生率［RR＝0.38，95%CI(0，.23，0.62)，P＝0.000 1］显著降低。结论急性胰腺炎病人应用奥曲肽治疗时，微量输液泵静脉滴注明显优于直接静脉滴注方式。 |
| 英文摘要: |
| Objective To systematically evaluate the efficacy of octreotide in different administration on the acute pancreatitis，in order to provide evidences for the choice of administration of octreotide in patients with acute pancreatitis.Methods Databases，in? cluding PubMed，Embase，Cochrane Library，ClinicalTrials，ScienceDirect，CNKI，CBM and Wanfang Data were searched to collectrandomized controlled trials on the effect of octreotide in different administration on the acute pancreatitis.The RevMan 5.3.5 soft?ware was used to carry out the Meta analysis.Results Sixteen RCTs with 1 266 patients were enrolled in this study.Meta analysisresults showed that as for continuous injection of octreotide with micro infusion pump，in comparison with direct intravenous injec? tion，the clinical total efficacy［RR＝3.14，95%CI(2.09，4.72)，P＜0.000 01］was significantly higher，the time of symptom disappear? ance［MD＝-1.53，95%CI(-1.71，-1.35)，P＜0.000 01］the recovery time of blood amylase［MD＝-2.83，95%CI(-3.04，-2.62)， P＜0.000 01］，time for resuming to diets［MD＝-2.30，95%，CI(-2.62，-1.98)，P＜0.000 01］，time for relieving symptoms of ab? dominal pain［MD＝-1.51，95%CI(-1.78，-1.25)，P＜0.000 01］and hospital stay［MD＝-3.56，95%CI(-3.82，-3.30)，P＜0.000 01］ were significantly shorter and the adverse reaction of total incidence rate［RR＝0.38，95%CI(0.23，0.62)，P＝0.000 1］was lower. Conclusion Compared with the direct intravenous injection，the micro infusion pump for continuous injection has better efficacy on the acute pancreatitis. |
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