| 熊旭东.糖皮质激素治疗特发性肺纤维化急性加重的研究进展[J].安徽医药,2020,24(3):425-428. |
| 糖皮质激素治疗特发性肺纤维化急性加重的研究进展 |
| Review on updates of glucocorticoids in treatment of acute exacerbation of idiopathic pulmonary fibrosis |
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| DOI：10.3969/j.issn.1009?6469.2020.03.001 |
| 中文关键词: 特发性肺纤维化 糖皮质激素类 铁蛋白质类 巨噬细胞炎性蛋白质类 白细胞介素类 综述 |
| 英文关键词: Idiopathic pulmonaryfibrosis Glucocorticoids Ferritins Macrophageinflammatoryproteins Interleukins Review |
| 基金项目:上海市科学技术委员会医学引导类科技支撑项目( 16401930300) |
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| 中文摘要: |
| 糖皮质激素作用机制有基因组机制和非基因组机制两类，其快速而有效的抑制炎症作用主要依赖于非基因组机制。现今临床学者大多采用大剂量糖皮质激素进行冲击治疗，通过非基因组机制来使糖皮质激素快速发挥抗炎以及抗纤维化效应，但具体的“扳机点”仍处于摸索阶段。临床及病理研究提示，特发性肺纤维化急性加重( AE?IPF)的特征性病理表现为弥漫性肺泡损伤( DAD)。糖皮质激素能够抑制核因子受体和促炎细胞因子的转录以及抑制纤维细胞增生和减少胶原沉积，以致于控制 DAD。但糖皮质激素在 AE?IPF中具体剂量以及维持时间仍存在很多争议。 |
| 英文摘要: |
| The mechanism of glucocorticoids involves genomic and non?genomic theory，and glucocorticoids exert rapid anti?inflam?matory effect through non?genomic mechanism.The high?doses glucocorticoids pulse treatment are adopted by most clinicians nowa?days，which has rapid non?genomic effect on anti?inflammation and anti?fibrosis.However，its specific "trigger point" is still underexploration.Clinical researches indicate that pathological changes of acute exacerbation of idiopathic pulmonary fibrosis(AE?IPF) is characterized by diffuse alveolar damage(DAD).Glucocorticoids are capable of inhibiting transcription of nuclear factor recep?tors and pro?inflammatory cytokines as well as inhibiting fibroblast proliferation and reducing collagen deposition so as to controlDAD.However，there are still many controversies on the specific dose and duration of glucocorticoids in AE?IPF. |
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