| 李靖,曹参,吴勤研,等.碳酸司维拉姆对终末期肾脏病并发高磷血症病人磷钙及低密度脂蛋白胆固醇水平的影响[J].安徽医药,2020,24(3):583-586. |
| 碳酸司维拉姆对终末期肾脏病并发高磷血症病人磷钙及低密度脂蛋白胆固醇水平的影响 |
| Effects of Stevenram Carbonate on the levels of phosphorus calcium and low density lipoprotein cholesterol in patients with end?stage renal disease complicated with hyperphosphatemia |
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| DOI：10.3969/j.issn.1009?6469.2020.03.041 |
| 中文关键词: 肾功能衰竭，慢性 碳酸司维拉姆 高磷血症 磷 钙 胆固醇， LDL 终末期肾病 |
| 英文关键词: Kidney failure,chronic Sevillam carbonate Hyperphosphatemia Phosphorus Calcium Cholesterol,LDL End?stage renal disease |
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| 中文摘要: |
| 目的分析终末期肾脏病并发高磷血症病人应用碳酸司维拉姆治疗对磷钙及低密度脂蛋白胆固醇水平的影响。方法选取的 110例终末期肾脏病并发高磷血症病人由东部战区总医院于 2016年 4月至 2018年 6月收诊，使用随机数字表法，分别划分为研究组和对照组，每组各 55例。研究组予以碳酸司维拉姆片治疗， 0.8克/次， 3次/天，每次服用的最大给药剂量不得超过 2.4 g，与三餐的第 1口饭同服。对照组予以醋酸钙治疗， 0.6克/次， 3次/天，每次服用的最大给药剂量不得超过 2.4 g，与三餐的第 1口饭同服。两组研究治疗期均为 8周。比较两组病人在治疗前和治疗后的血磷、校正血钙、钙磷乘积、全段甲状旁腺激素( iPTH)值、低密度脂蛋白胆固醇( LDL?C)、碳酸氢盐水平。结果研究组病人治疗后的血磷、校正血钙值、钙磷乘积值、 LDL? C和碳酸氢盐水平分别为( 1.83±0.25)mmol/L、(2.03±0.15)mmol/L、(4.17±0.52)mmol2/L2、(1.81±0.31)mmol/L、(16.8±1.1)mmol/L，均低于对照组( 2.35±0.43)mmol/L、(2.24±0.27)mmol/L、(4.73±0.74)mmol2/L2、(2.30±0.45)mmol/L、(18.0±1.3)mmol/L，差异有统计学意义( P＜0.05)。研究组 iPTH值( 368.1±13.9)ng/L，对照组 iPTH值( 365.2±13.9)ng/L，差异无统计学意义( P＞0.05)。结论碳酸司维拉姆片应用于终末期肾脏病并发高磷血症病人，能降低人体的血磷、血钙以及 LDL?C水平，使病人在用药过程获得更高的安全性，值得临床进一步推广应用。 |
| 英文摘要: |
| Objective To analyze the effects of Stevenram Carbonate on the levels of phosphorus，calcium and low density lipopro? tein cholesterol in patients with end?stage renal disease complicated with hyperphosphatemia.Methods A total of 110 patientswith end?stage renal disease complicated with hyperphosphatemia were admitted to General Hospital of Eastern Theater Commandfrom April 2016 to June 2018.They were divided into study group and control group by random number table method，with 55 cases in each group.The study group was treated with stevenram carbonate tablets，0.8 g/time，3 times/day，with the maximum dose of each dose not exceeding 2.4 g，taken with the first bite of each meal.The control group was treated with calcium acetate，0.6 g/time， 3 times/d，with the maximum dose of each dose not exceeding 2.4 g，which was taken with the first bite of each meal.The treatment period of the two groups was 8 weeks.Blood phosphorus，corrected blood calcium，calcium?phosphorus product，total parathyroid hor? mone(iPTH)value，low density lipoprotein cholesterol(LDL?C)，and bicarbonate levels were compared between the two groups be? fore and after treatment.Results The serum phosphorus，corrected serum calcium value，product value of calcium and phosphorus， LDL?C and bicarbonate levels in the study group were(1.83±0.25)mmol/L，(2.03±0.15)mmol/L，(4.17±0.52)mmol2/L2，(1.81±0.31)mmol/L and(16.8±1.1)mmol/L，respectively.Compared with the control group(2.35±0.43)mmol/L，(2.24±0.27)mmol/L，(4.73±0.74)mmol2/L2，(2.30±0.45)mmol/L，and(18.0±1.3)mmol/L，the differences were statistically significant(P＜0.05).IPTH values in the study group(368.1±13.9)ng/L and in the control group(365.2±13.9)ng/L showed no significant difference(P＞ 0.05).Conclusion The application of Stevenram Carbonate tablets in patients with end?stage renal disease complicated with hyper?phosphatemia can reduce the level of serum phosphorus and calcium，and reduce the level of low?density lipoprotein cholesterol，so that patients can obtain higher safety in the course of drug use. |
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