| 葛苗苗,罗立,杜帅先,等.某医院 8年间鲍曼不动杆菌耐药与抗菌药物用量的相关性分析[J].安徽医药,2020,24(3):623-626. |
| 某医院 8年间鲍曼不动杆菌耐药与抗菌药物用量的相关性分析 |
| Study on the relationship between drug resistance rate of Acinetobacter baumanii and antibiotics usage of 8 years in one hospital |
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| DOI：10.3969/j.issn.1009?6469.2020.03.052 |
| 中文关键词: 鲍曼不动杆菌 抗菌药 抗药性，细菌 耐药率 使用强度 相关性 |
| 英文关键词: Acinetobacter baumannii Anti?bacterial agents Drug resistance,bacterial Drug resistance rate Use density Relationship |
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| 摘要点击次数: 1936 |
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| 中文摘要: |
| 目的分析某医院住院病人鲍曼不动杆菌耐药率和抗菌药物用量之间的关系，为临床合理用药和控制细菌耐药提供参考依据。方法采用回顾性调查方法，对华中科技大学同济医学院附属协和医院 2010年 1月至 2017年 12月住院病人常用抗菌药物的使用强度及鲍曼不动杆菌耐药率进行统计，并采用 SPSS 23.0统计软件对其进行 Spearman相关性分析。结果 8年共检出鲍曼不动杆菌 10 885株，除米诺环素、替加环素、多黏菌素 B及头孢哌酮舒巴坦外，对常用的 16种抗菌药物耐药率均已高达 80％左右。鲍曼不动杆菌对替加环素的耐药率与其抗菌药物使用强度高度正相关( r＝0.994，P＝0.006)；对美罗培南耐药率与其使用强度呈中度正相关( r＝0.717，P＝0.045)；对哌拉西林 /他唑巴坦的耐药率也与其使用强度呈中度正相关( r＝ 0.791，P＝0.019)。结论鲍曼不动杆菌的耐药率与替加环素、美罗培南、哌拉西林 /他唑巴坦用量存在中 -高度相关性，应加强这些药物的临床合理应用管理，遏制和延缓医院鲍曼不动杆菌耐药率的增长。 |
| 英文摘要: |
| Objective To investigate the relationship between the drug resistance rate of Acinetobacter baumannii and antibiotic consumption，and provide the reference for rational drug use in clinic and control of bacterial resistance.Methods The drug resis? tance rate of A.baumannii and the antibiotics use density(AUD)were retrospectively analyzed in Union Hospital，Tongji Medical Col? lege，Huazhong University of Science and Technology from January 2010 to December 2017.And Spearman correlation analysis wasperformed using SPSS 23.0 statistical software.Results 10 885 strains of A.baumannii were detected in 8 years.Except for minocy? cline，tigecycline，polymyxin B and cefoperazone sulbactam，the resistance rates of 16 antimicrobial agents commonly used were all ashigh as 80%.The resistance rate of Acinetobacter baumannii to tigecycline was highly positively correlated with the AUD(r＝0.994， P＝0.006).It was medium positive correlation between the resistance rate to meropenem and its AUD(r＝0.717，P＝0.045).The re? sistance rate to piperacillin tazobactam was also positively?moderately correlated with its AUD(r＝0.791，P＝0.019).Conclusion The drug resistance rate of Acinetobacter baumannii is highly correlated with the usage of tigecycline，meropenem，piperacillin/tazo? bactam.The clinical rational application management of these drugs should be strengthened，to control and delay the increase of re? sistance rate to Acinetobacter baumannii in hospital. |
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