| 钱贝丽,韩若东,颜秀侠.急性重度有机磷中毒 96例认知障碍影响因素临床研究[J].安徽医药,2020,24(4):684-687. |
| 急性重度有机磷中毒 96例认知障碍影响因素临床研究 |
| Clinical study on influencing factors of cognitive dysfunction in 96 patients with acute severe organophosphorus poisoning |
| |
| DOI：10.3969/j.issn.1009?6469.2020.04.012 |
| 中文关键词: 杀虫药/中毒 有机磷化合物 认知障碍 胆碱酯酶类 |
| 英文关键词: Insecticides/poisoning Organophosphorus compounds Cognition disorders Cholinesterases |
| 基金项目:2016年度黎介寿肠道屏障研究专项基金( LJS?201605) |
|
| 摘要点击次数: 1689 |
| 全文下载次数: 506 |
| 中文摘要: |
| 目的探讨急性重度有机磷中毒病人认知障碍影响因素。方法 2016年 1月至 2019年 1月安徽医科大学附属亳州临床学院(亳州市人民医院)收治的 96例经口急性重度有机磷中毒病人，根据有无认知障碍分为无认知障碍组 79例和认知障碍组 17例。比较两组资料，采用多因素 logistic回归分析急性重度有机磷中毒病人认知障碍影响因素。结果急性重度有机磷中毒病人认知障碍的发病率为 17.7%(17/96)；认知障碍组病人年龄、急性生理健康评分 ?Ⅱ、胆碱酯酶( CHE)恢复时间、住院时间分别为( 58.59±8.85)岁、(21.53±2.92)分、(9.17±1.07)d、(20.06±7.20)d，均大于无认知障碍组［(42.85±12.26)岁、(15.14±3.90)分、(4.49±2.33)d、(11.00±6.68)d］(P＜0.05)；两组病人农药中毒类别、性别比较均差异无统计学意义( P＞0.05)；无认知障碍组病人入院初血糖、动脉血气 PH值及，乳酸与认知障碍组比较均差异无统计学意义( P＞0.05)；多因素 logistic回归分析示 CHE恢复时间( OR＝1.865，95%CI1.190～2.923，P＝0.007)是急性重度有机磷中毒病人认知障碍发生的危险因素。结论 CHE恢复时间是急性重度有机磷中毒病人发生认知障碍的危险因素，临床应重视 CHE恢复时间，及时评估病人是否伴有认知功能障碍。 |
| 英文摘要: |
| Objective To explore the influencing factors of cognitive impairment in patients with Acute severe organophosphorus pesticide poisoning(ASOPP).Methods Ninety?six patients with ASOPP who were admitted to the Department of Critical Medi? cine，Bozhou Clinical College Affiliated to Anhui Medical University from January 2016 to January 2019 were assigned into twogroups according to the existence of cognitive impairment.Group A was non?cognitive impairment group with 79 cases，while groupB was cognitive impairment group with 17 cases.The basic data of the two groups were compared and the influencing factors of cog?nitive impairment in patients with ASOPP were analyzed by multivariate logistic regression.Result The incidence of cognitive im? pairment in ASOPP was 17.7%(17/96).The age［(58.59±8.85)years vs.(42.85±12.26)years］acute physiological health score?II(APACHE?II)［(21.53±2.92)scores vs.(15.14±3.90)scores］，recovery time of cholinesterase［(9，.17±1.07)d vs.(4.49±2.33)d］ and hospital stay time［(20.06±7.20)d vs.(11.00±6.68)d］in group B were respectively higher than those in group A(P＜0.05). There were no significant differences between the two groups on the types of pesticide poisoning and gender(P＞0.05).There were no significant differences between the two groupson initial blood sugar［( 18.08±3.17)mmol/L vs.(18.58±4.12)mmol/L］，arterial blood gas Ph［(7.29±0.13)vs.(7.28±0.12)］and lactate［(2.52±0.61)mmol/L vs.(2.60±0.45 mmol/L］( P＞0.05).Multivariate lo? gistic regression analysis indicated that the recovery time of cholinesterase was a risk factor for cognitive impairment in patientswith acute severe organophosphorus poisoning(OR＝1.865，95%CI:1.190?2.923，P＝0.007).Conclusion Recovery time of cholin?esterase is the risk factor of cognitive impairment in patients with acute severe organophosphorus poisoning.Clinicians should payattention on the recovery time of cholinesterase and assessment of patients with cognitive impairment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
