| 赖雪芹,赵青,郭健秋,等.N端前脑钠肽与原田危险评分、小林评分对川崎病病儿冠状动脉病变风险预测价值的对比[J].安徽医药,2020,24(4):688-691. |
| N端前脑钠肽与原田危险评分、小林评分对川崎病病儿冠状动脉病变风险预测价值的对比 |
| Comparison of NT?proBNP，Harada risk score and Kobayashi score in predicting coronary artery disease risk in children with Kawasaki disease |
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| DOI：10.3969/j.issn.1009?6469.2020.04.013 |
| 中文关键词: 黏膜皮肤淋巴结综合征/并发症 冠状动脉疾病 利钠肽，脑 危险因素 原田危险评分 小林评分 儿童 |
| 英文关键词: Mucocutaneous lymph node syndrome/complications Coronary artery disease Natriuretic peptide,brain Risk factor Harada risk score Kobayashi score Child |
| 基金项目:东莞市社会科技发展(一般)项目( 2018507150241548) |
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| 中文摘要: |
| 目的研究 N端前脑钠肽( N?terminal pro?brain natriuretic peptide，NT?proBNP)与原田危险评分、小林评分对川崎病病儿冠状动脉病变风险的预测价值。方法选取 2017年 6月至 2018年 12月于东莞市第三人民医院就诊的 45例川崎病病儿，根据病儿是否存在冠状动脉病变，将病儿分为病变组( 26例)和未病变组( 19例)。入院后测定病儿血浆 NT?proBNP水平，并记录病儿的一般临床资料、原田危险评分、小林评分、白细胞( WBC)、血小板( PLT)和 C反应蛋白( CRP)等。结果病变组年龄低于未病变组， WBC(14.45±3.75)×109/L、中性粒细胞( 7.78±1.58)×109/L、PLT(391.35±51.23)×109/L、CRP(83.56±14.74)mg/L、NT?proB? NP(756.43±87.56)pg/mL、原田危险评分( 5.66±1.15)分和小林评分( 7.65±1.42)分均高于未病变组［( 10.67±3.81，6.76±1.67， 354.61±63.71，62.45±15.68，567.29±61.39，4.37±1.16，6.39±1.28)(均 P＜0.05)］；两组病儿性别和 BMI均差异无统计学意义( P＞0.05)。ROC曲线显示， NT?proBNP的 AUC为 0.941，高于原田危险评分的 0.761和小林评分的 0.823(Z＝2.136、1.993，P＝0.033、0.046)； Y |
| 英文摘要: |
| Objective To compare the predictive values of N?terminal pro?brain natriuretic peptide(NT?proBNP)，Harada risk score and Kobayashi score for coronary artery disease risk in children with Kawasaki disease.Methods Totally 45 cases of Kawa?saki disease were selected from Dongguan Songshan Lake Central Hospital Hospital who were treated from June 2017 to December2018 and assigned，according to the presence or absence of coronary artery disease，into lesion group(26 cases)and non?lesion group(19 cases).The plasma NT?proBNP level was measured after admission.The general clinical data，Harada risk score，Kobayas? hi score，white blood cell(WBC)，platelets(PLT)and C?reactive protein(CRP)were recorded.Results The age of lesion group was significantly lower than that of non?lesion group.WBC(14.45±3.75)×109/L，neutrophil(7.78±1.58)×109/L，PLT(391.35± 51.23)×109/L，CRP(83.56±14.74)mg/L，NT?proBNP(756.43±87.56)pg/mL，Harada risk score(5.66±1.15)and Kobayashi score(7.65±1.42)were significantly higher than those of non?lesion group(10.67±3.81，6.76±1.67，354.61±63.71，62.45±15.68，567.29± 61.39，4.37±1.16，6.39±1.28，respectively)( all P＜0.05)，and there were no significant differences in gender and BMI between the two groups(P＞0.05).ROC curve showed that the AUC of NT?proBNP was 0.941，significantly higher than that of Harada risk score 0.761 and Kobayashi score 0.823，with statistical difference(Z＝2.136，1.993，P＝0.033，0.046).Youden index suggested that the best cut?off points for NT?proBNP，Harada risk score and Kobayashi score in predicting the risk of coronary artery disease in chil?dren with Kawasaki disease were 654.44 pg/mL，5.00 points and 7.13 points，respectively.The sensitivity of NT?proBNP in predictingthe risk of coronary artery disease in children with Kawasaki disease was 88.46%，higher than 65.38% of Harada risk score and |
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