| 孟文颖,李小庆,王雅丽.孕妇阻塞性睡眠呼吸暂停低通气综合征对母婴结局的影响[J].安徽医药,2020,24(4):708-711. |
| 孕妇阻塞性睡眠呼吸暂停低通气综合征对母婴结局的影响 |
| Effect of obstructive sleep apnea hypopnea syndrome on maternal and infant outcome in pregnant women |
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| DOI：10.3969/j.issn.1009?6469.2020.04.018 |
| 中文关键词: 睡眠呼吸暂停，阻塞性 打鼾 妊娠并发症 高血压，妊娠性 睡眠 妊娠结局 婴儿，新生 |
| 英文关键词: Sleep apnea,obstructive Snoring Pregnancy?induced complications Hypertension,pregnancy?induced Sleep Pregnancy outcome Infant,newborn |
| 基金项目:通州区妇幼保健院重点学科建设( KJ2016CX044) |
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| 中文摘要: |
| 目的探讨孕妇阻塞性睡眠呼吸暂停低通气综合征( OSAHS)对母婴结局的影响。方法回顾性分析 2016年 1月至 2017年 1月于北京市通州区妇幼保健院产科建档的 1 999例孕妇的临床资料。按照病情情况，其分为 OSAHS组和非 OSAHS组， OSAHS组 593例，非 OSAHS组 1 406例，在妊娠第 13周、 28周及分娩前调查孕妇睡眠打鼾情况、测量孕妇生理生化指标，记录产后新生儿资料。比较两组的临床特征、孕妇分娩结局和新生儿结局。结果 OSAHS组的孕前体质量指数( BMI)高于非 OSAHS组，产次低于非 OSAHS组，均差异有统计学意义( P＜0.05)。两组的年龄、孕次相比，差异无统计学意义( P＞0.05)。 OSAHS组孕妇的妊娠高血压综合征、慢性高血压、子痫前期、慢性高血压并发子痫前期、早产和妊娠糖尿病的发生率( 5.23%、 4.22%、7.25%、1.52%、24.79%、8.09%)明显高于非 OSAHS组( 1.99%、2.00%、1.49%、0.21%、14.44%、4.69%)，差异有统计学意义(χ2＝15.250、21.091、44.618、11.885、30.943、149.164，P＜0.05)。孕周［( 30.18±4.02)周］明显少于非 OSAHS组［( 33.60±5.50)周］，差异有统计学意义( t＝16.957，P＜0.05)。两组的产后出血发生率相比，差异无统计学意义( P＞0.05)。 OSAHS组的新生儿窒息的发生率、 Apgar评分＜ 7分的比例( 12.82%、3.36%)均明显高于非 OSAHS组( 4.62%、0.92%)差异有统计学意义( χ2＝ |
| 英文摘要: |
| Objective To explore the effect of obstructive sleep apnea hypopnea syndrome(OSAHS)on the outcome of pregnant women.Methods The clinical data of 1999 pregnant women registering at Department of Gynecology and Obstetrics，Maternal and Child Care Hospital in Tongzhou district of Beijing from January 2016 to January 2017 were analyzed retrospectively.According totheir condition，the women were assigned into OSAHS group(n＝593)and non?OSAHS group(n＝1406).The snoring situation of pregnant women at thirteenth weeks，28 weeks and before delivery was investigated，the physiological and biochemical indexes ofpregnant women were measured and the information of the newborn babies was recorded.The clinical characteristics，delivery out? come and neonatal outcome of the two groups were compared. Results The progestational body mass index(BMI) of OSAHS group was higher than that of non?OSAHS group，and the number of births was lower than that of non?OSAHS group；the difference showed a statistical significance(P＜0.05).There were no significant differences in age and gravida between the two groups(P＞ 0.05).The incidences of pregnancy?induced hypertension syndrome，chronic hypertension，preeclampsia，chronic hypertension com? plicated by preeclampsia，preterm delivery and gestational diabetes in OSAHS group(5.23%，4.22%，7.25%，1.52%，24.79%,8.09%)were significantly higher than those in non?OSAHS group(1.99%，2.00%，1.49%，0.21%，14.44%，4.69%)； the differences were statistically significant(χ2＝15.250，21.091，44.618，11.885，30 943，149.164，respectively；P＜0.05). Gestational week［(30.18±4.02)weeks］of OSAHS group was significantly shorter than that of non?OSAHS group［(33.60±5.50)weeks］； the differ? ence was statistically significant(t＝16.957，P＜0.05).There was no significant difference in the incidence of postpartum hemor? rhage between the two groups(P＞0.05).The incidence of neonatal asphyxia and the proportion of Apgar score＜7 in the OSAHS group(12.82%，3.36%)were significantly higher than those in the non?OSAHS group(4.62%，0.92%)； the differences were statisti? cally significant(χ2＝3.124，3.295，respectively；P＜0.05).There were no significant differences between the two groups in terms of neonatal weight，incidence of macrosomia，incidence of fetal growth restriction(FGR)and incidence of umbilical cord around neck(P＞0.05).Conclusions OSAHS of pregnant women is closely related to the occurrence of pregnancy?induced hypertension syn? drome，chronic hypertension，preeclampsia，chronic hypertension complicated by preeclampsia，premature delivery and GDM，which will affect the development of fetus，and we should strengthen the perinatal health care of snoring pregnant women and improve the maternal and infant outcome. |
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