| 任孟先,钱立庭,刘艳,等.调强放疗联合肝动脉化疗栓塞术治疗原发性肝癌的有效性与安全性研究[J].安徽医药,2020,24(5):951-954. |
| 调强放疗联合肝动脉化疗栓塞术治疗原发性肝癌的有效性与安全性研究 |
| Efficacy and safety of intensity modulated radiotherapy combined with TACE in the treatment of primary liver cancer |
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| DOI：10.3969/j.issn.1009?6469.2020.05.026 |
| 中文关键词: 癌，肝细胞 放射疗法，调强适形 化学栓塞，治疗性 肝动脉 奥沙利铂 |
| 英文关键词: Carcinoma,hepatocellular Radiotherapy,intensity?modulated Chemoembolization,therapeutic Hepatic artery Oxaliplatin |
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| 中文摘要: |
| 目的探讨调强放疗( IMRT)联合肝动脉化疗栓塞术( TACE)治疗中晚期原发性肝癌的有效性与安全性。方法回顾性分析太和县人民医院 2008年 9月至 2015年 9月收治的中晚期原发性肝癌病人 70例，分为联合组 36例与单纯组 34例，联合组采用 IMRT联合 TACE治疗，单纯组采用 TACE治疗，比较两组病人近期有效率， 6个月、 1年、 2年生存率及不良反应发生率。结果联合组总有效率( CR+PR)为 66.7%，显著优于单纯组总有效率( CR+PR)41.2%，差异有统计学意义( Z＝-2.367，P＝ |
| 英文摘要: |
| Objective This study was designed to evaluate the efficacy and safety of intensity modulated radiotherapy(IMRT)com? bined with transarterial chemoembolization(TACE)in the treatment of advanced hepatocellular carcinoma.Methods 70 patients who were with advanced primary liver cancer and treated in The People’s Hospital of Taihe from September 2008 to September 2015 were randomly divided into two groups，the combined group(36 cases)and the control group(34 cases).The combined group was treated with IMRT combined with TACE，and the control group was treated with TACE alone.The short?term effective rate，6 months，1?year，2?year survival rate and adverse reaction rate were compared between the two groups.Results The total effective rate of the combined group was 66.7%，which was significantly better than that of the control group(41.2%).The difference was sta? tistically significant(Z＝-2.367，P＝0.018).The 6?month，1?year and 2?year survival rates of the two groups were100%，91.7%，72.2% and 88.2%，64.7%，35.3%，respectively.The median OS were 28 months(95%CI:24.7~31.3)and 20 months(95%CI:12.9~27.1)， respectively.There was a significant difference in the distribution of the survival curve between the two groups(χ2＝3.988，P＝0.046). There was no difference in general adverse reactions between the two groups.There were 3 cases of atypical RILD in the combined group，which were improved by conservative treatment.Conclusion IMRT combined with TACE can effectively improve the prog? nosis of patients with advanced primary liver cancer，prolong the survival time and not increase the incidence of adverse reactions. |
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