| 邵文真,郑伟.乳腺滴灌疗法联合红金消结片治疗乳腺增生症 50例[J].安徽医药,2020,24(5):1003-1006. |
| 乳腺滴灌疗法联合红金消结片治疗乳腺增生症 50例 |
| Fifty cases of breast mammary gland hyperplasia treated through mammary duct drip irrigation combined with Hongjin Xiaojie tablet |
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| DOI：10.3969/j.issn.1009?6469.2020.05.039 |
| 中文关键词: 乳腺纤维囊性病 白细胞介素 6 白细胞介素 8 肿瘤坏死因子 α 抗原， CD3 抗原， CD4 抗原， CD8 投药，局部 乳腺滴灌疗法 红金消结片 免疫系统 |
| 英文关键词: Fibrocystic disease of breast Interleukin?6 Interleukin?8 Tumor necrosis factor?alpha Antigens,CD3 Antigens, CD4 Antigens,CD8 Administration,topical Mammary duct drip irrigation Hongjin Xiaojie tablets Immune system |
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| 中文摘要: |
| 目的探讨乳腺滴灌疗法联合红金消结片治疗乳腺增生症的效果以及对免疫系统的影响。方法选取 2017年 6月至 2018年 6月滨州市妇幼保健院乳腺增生症病人 100例，采用随机数字表法分为单一组和联合组，各 50例。单一组病人采用乳腺导管滴灌的方法(药物为阿米卡星、地塞米松、 0.9%氯化钠溶液、利多卡因、玻璃酸酶与曲安奈德)进行治疗，联合组在单一组基础上增加红金消结片进行治疗，对比两组病人的治疗效果，并以病人血清白介素 6(IL?6)、白介素 8(IL?8)、肿瘤坏死因子 α(TNF?α)水平为观察指标，对比两组治疗前后的炎性因子的变化情况，并对比两组治疗前后的分化簇 3(CD3+T)、分化簇(4CD4+T)、分化抗原 CD8(CD8+T)、自然杀伤细胞( NK细胞)水平，评价其免疫能力，并调查病人对治疗的满意度。结果联合组病人治疗的总有效率为 90％，显著高于单一组病人的 72％( P＜0.05)；治疗后两组病人的 IL?6、IL?8、TNF?α水平均有显著改善，且联合组病人的改善情况显著优于单一组病人( P＜0.05)；治疗后两组 CD3+T、CD4+T、CD8+T、NK细胞水平均有显著改善，且联合组病人改善情况显著优于单一组病人( P＜0.05)；联合组病人对治疗效果的满意度为 94％，显著高于单一组病人的 74％( P＜0.05)。结论乳腺滴灌疗法与红金消结片联合治疗乳腺增生症比乳腺滴灌疗法单一治疗效果更好，而且对于病人炎性因子及免疫能力的改善也有着更好的效果，提高了病人治疗满意度。 |
| 英文摘要: |
| Objective To investigate the effects of mammary duct drip irrigation combined with Hongjin Xiaojie tablet on mammary gland hyperplasia and the influence on the immune system of patients.Methods A total of 100 patients receiving treatment formammary hyperplasia in Binzhou Maternal and Child Health Hospital from June 2017 to June 2018 were selected and divided intothe single group and the combined group by random number table method，with 50 case in each group.Patients in the single group underwent monotherapy of mammary duct drip irrigation(amikacin，dexamethasone，saline，lidocaine，hyaluronidase and triamcino? lone)，while patients in the combined group were treated with Hongjin Xiaojie tablets plus mammary duct drip irrigation.The thera?peutic efficacy and the satisfaction of patients after treatment between the two groups were compared in terms of qualitative datawith χ2 test.The alterations of inflammatory factors，interleukin?6(IL?6)，interleukin?8(IL?8)and tumor necrosis factor?α(TNF?α) and the immune cells including CD3+ T cell，CD4+ T cell，CD8+ T cell and NK cell between both groups were compared in view of quantitative data with t test.Results The total effective rate of the combined group was 90%，which was significantly higher than that in the single group(72%)( P＜0.05).The levels of IL?6，IL?8 and TNF?α in both groups were significantly reduced after treat? ment，and those in combined group were significantly decreased as compared to those in single group(P＜0.05).The levels of CD3+ T cell，CD4+ T cell，CD8+T cell and NK cell in both groups were significantly increased after treatment，meanwhile，those in the combined group were significantly higher than those in the single group after treatment(P＜0.05).The satisfaction of patients in the combined group was 94%，which was significantly greater than that in the single group of 74%(P＜0.05).Conclusion The combination therapy exhibits advantages including improved therapuetic efficacy，decreased inflammatory factors level and in?creased immunological ability in treating the breast hyperplasia patients when compared to the mammary duct drip irrigation alone. |
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