| 郝文杰,杨文明.肝型肝豆状核变性病人血尿酸水平变化及其与肝功能和凝血常规指标相关性研究[J].安徽医药,2020,24(6):1113-1116. |
| 肝型肝豆状核变性病人血尿酸水平变化及其与肝功能和凝血常规指标相关性研究 |
| Changes of serum uric acid level in patients with hepatolenticular degeneration and its correlation with liver function and blood coagulation |
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| DOI：10.3969/j.issn.1009?6469.2020.06.013 |
| 中文关键词: 肝豆状核变性 尿酸 肝功能试验 天冬氨酸氨基转移酶类 丙氨酸转氨酶 胆红素 凝血酶原时间 |
| 英文关键词: Hepatolenticular degeneration Uric acid Liver function tests Aspartate aminotransferases Alanine transami?nase Bilirubin Prothrombin time |
| 基金项目:国家自然科学基金( 81373599)；国家中医药管理局中医药防治重大疑难疾病(肝豆状核变性)临床防治中心建设项目(国中医药办规财发〔2013〕41号) |
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| 中文摘要: |
| 目的观察肝型肝豆状核变性病人血尿酸变化水平，分析该型病人血尿酸水平与肝功能、凝血指标之间的相关性。方法选取 2017年 8月至 2018年 8月在安徽中医药大学第一附属医院脑病中心肝型肝豆状核变性住院病人 50例作为 HLD组，健康人群 30例作为健康组，统计分析两组血尿酸水平是否存在差异，与肝功能、凝血指标是否存在相关性。结果 HLD组中血尿酸水平( 127.28±25.55)μmol/L与健康组( 257.1±47.53)μmol/L比较， HLD组中血尿酸水平显著降低( P＜0.05)； HLD组中轻、中、重度三种不同病情程度之间血尿酸水平( 150.24±21.27)μmol/L、(117.33±9.37)μmol/L和( 99.73±5.02)μmol/L均显著不同，随着病情程度的加重，血尿酸的水平逐渐降低( P＜0.05)； HLD组中 AST(天冬氨酸氨基转移酶)、 ALT(丙氨酸氨基转移酶)及 PT(凝血酶原时间)水平与健康组相比显著升高( P＜0.05)； HLD组中轻、中、重度三种不同病情程度之间 AST、ALT及 PT的水平明显不同，随着病情程度的加重，其水平逐渐升高( P＜0.05)；重度组中总胆红素及白蛋白的水平与轻、中度组相比差异有统计学意义( P＜0.05)；血尿酸与 AST存在高度负相关( r＝-0.755，P＜0.01)与 ALT(r＝-0.698，P＜0.01)及 PT(r＝-0.649，P＜ |
| 英文摘要: |
| Objective To observe the level of serum uric acid in patients with hepatolenticular degeneration(HLD)and to analyze the correlation between the level of serum uric acid and liver function and blood coagulation indexes.Methods Fifty inpatientswith encephalopathy treated in The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from August 2017to August 2018were selected as the HLD group and 30 healthy people as the healthy group.Statistical analysis was made to find outwhether the levels of serum uric acid of the two groups were different，and whether there was a correlation between the level of se? rum uric acid and liver function and coagulation indicators.Results Serum uric acid level in HLD group was significantly lower than that in healthy group［( 127.28±25.55)μmol/L vs.(257.1±47.53)μmol/L，P＜0.05］.Serum uric acid levels were significantly different with the severity of the disease among mild，moderate and severe cases in HLD group［(150.24±21.27)μmol/L，(117.33± 9.37)μmol/L and(99.73±5.02)μmol/L］，which gradually decreased with the worsening of the disease(P＜0.05).The aspartate ami? notransferase(AST)，alanine aminotransferase(ALT)and prothrombin time(PT)levels in the HLD group were significantly high? er than those in the healthy group(P＜0.05).The levels of AST，ALT and PT were significantly different among the mild，moderate and severe cases in HLD groups，which gradually increased with the worsening of the disease(P＜0.05).Total bilirubin and albu? min levels in the severe cases were significantly different from those in the mild and moderate cases(P＜0.05).Serum uric acid level had a high negative correlation with AST(r＝-0.755，P＜0.01)，a moderate negative correlation with ALT(r＝-0.698，P＜0.01)and PT(r＝-0.649，P＜0.01)，and a low negative correlation with total bilirubin(r＝-0.346，P＜0.01).There was a moder? atepositive correlation between serum uric acid and albumin(r＝-0.656，P＜0.01).Conclusion The serum uric acid level in pa? tients with hepatolecular degeneration was lower than that in healthy people，which was negatively correlated with liver function in? dexes AST，ALT and coagulation routine index PT. |
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