| 蒋艳,徐曼,汪向明,等.CD34、CD10、Ki?67、细胞周期蛋白 D1联合应用在乳腺良性叶状肿瘤诊断中的价值[J].安徽医药,2020,24(8):1515-1518. |
| CD34、CD10、Ki?67、细胞周期蛋白 D1联合应用在乳腺良性叶状肿瘤诊断中的价值 |
| Value of combined application of CD34，CD10，Ki?67 and CyclinD?1 in the diagnosis of benign phyllodes tumors of breast |
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| DOI：10.3969/j.issn.1009?6469.2020.08.008 |
| 中文关键词: 乳腺肿瘤/诊断 抗原， CD34 病理诊断 乳腺叶状肿瘤 纤维腺瘤 免疫组织化学 |
| 英文关键词: Breast neoplasms/diagnosis Antigens,CD34 Pathological diagnosis Breast phyllodes Fibroadenoma Immu? nohistochemistry |
| 基金项目:安徽省重点研究与开发计划项目(1704f0804049) |
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| 中文摘要: |
| 目的观察乳腺良性叶状肿瘤和纤维腺瘤的镜下形态学特点与免疫表型特征，并进一步探讨 CD34、CD10、Ki?67、细胞周期蛋白 D1(CyclinD?1)联合应用在两者鉴别诊断中的价值。方法筛选芜湖市第一人民医院 2016—2018年乳腺良性叶状肿瘤 62例，纤维腺瘤 73例，观察 HE组织学特征，并用免疫组化检测 CD34、CD10、Ki?67、CyclinD?1在肿瘤间质中的表达情况。结果良性叶状肿瘤与纤维腺瘤中 CD34的高表达(++及以上)阳性率分别为 93.5%，90.4%(P＞0.05)； CD10的高表达(++及以上)阳性率分别为 72.6%，45.2%(P＜0.05)； Ki?67的阳性表达率分别为 27.4%，6.8%(P＜0.05)； CyclinD?1的阳性表达率分别为 77.4%，47.9%(P＜0.05)；结论良性叶状肿瘤与纤维腺瘤免疫表型存在差异， CD34、CD10、Ki?67、CyclinD?1的联合应用对两者的鉴别诊断及病人的预后评估具有较大参考意义。 |
| 英文摘要: |
| Objective To observe the microscopic morphological and immunophenotypic features of benign phyllodes and fibroade? nomas of the breast，and to further explore the value of CD34，CD10，Ki?67 and CyclinD?1 in the differential diagnosis between them.Methods Sixty?two cases of breast benign phyllodes tumors and 73 cases of fibroadenoma in the First People’s Hospital ofWuhu City from 2016 to 2018 were screened.The histological characteristics of HE were observed.The expressions of CD34，CD10， Ki?67 and CyclinD?1 in the stroma of breast tumors were detected by immunohistochemistry.Results The positive rates of CD34(++ and above)in benign phyllodes tumors and fibroadenomas were 93.5% and 90.4%，respectively(P＞0.05)，the positive rates of CD10(++ and above)were 72.6% and 45.2%，respectively(P＜0.05)the positive rates of Ki?67 were 27.4% and 6.8%，respec? tivelty(P＜0.05)，and the positive rates of clinD?1 were 77.4% and 47.9%，respectively(P＜0.05).Conclusion There are differ? ences in immunophenotypes between benign phyllodes tumors and fibroadenomas.The combined use of CD34，CD10，Ki?67 and Cy?clinD?1 is of great significance in differential diagnosis and prognosis evaluation of patients with benign phyllodes tumors. |
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