| 葛尚清,杜瀛瀛,孙国平.40岁及以下肺癌病人的临床特征与总生存期随访数据分析[J].安徽医药,2020,24(8):1529-1533. |
| 40岁及以下肺癌病人的临床特征与总生存期随访数据分析 |
| Analysis of clinical characteristics and over?all survival follow?up data of lung cancer patients under 40 years of age |
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| DOI：10.3969/j.issn.1009?6469.2020.08.012 |
| 中文关键词: 肺肿瘤 青年人 临床特征 生存分析 |
| 英文关键词: Lung neoplasms Young adult Clinical characteristics Survival analysis |
| 基金项目:安徽省重点研究与开发计划项目(1704a0802163) |
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| 中文摘要: |
| 目的探索年轻肺癌(40岁及以下)临床特征及其与生存预后的关系，为预防和诊治提供参考。方法回顾性分析安徽医科大学第一附属医院 2000年 1月 1日至 2019年 7月 1日经治的 251例年轻肺癌病人的临床资料。所有纳入的病人诊断时年龄均 ≤40岁、死亡时间明确，且均经过病理或细胞学证实为原发性肺癌。绘制 Kaplan?Meier生存曲线，并进行 log?rank检验，将有统计学意义的因素引入 Cox回归模型，从而得出影响病人生存预后的独立因素。结果病人发病年龄(34.5±5.6)岁，年龄范围为 18~40岁，男女比例 1.13∶1.最常见的病理类型为腺癌，绝大多数病人诊断时 TNM分期即为晚期。最常见的就诊原因是咳嗽(55.8%)。远处转移的部位当中，骨(51.8%)最为多见。纤维支气管镜取材活检(37.1%)是应用最为广泛的明确诊断的方法。单因素分析结果显示，年轻肺癌病人的生存时间与吸烟史(P＝0.031)、病理类型(P＝0.040)和 TNM分期(P＜0.001)相关。多因素分析结果显示， TNM分期(P＜0.001)和病理类型(P＝0.004)是影响年轻肺癌病人生存预后的独立因素。结论腺癌和晚期是年轻肺癌病人最显著的临床特征，早期发现使年轻肺癌病人更受益。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics and their relationship with the prognosis of young lung cancer pa?tients so as to provide guidance for its prevention，diagnosis and treatment.Methods The records of patients under the age of 40with pathologically diagnosed lung cancer at the 1st Affiliated Hospital of Anhui Medical University from January 1，2000 to July 1， 2019 were retrospectively reviewed and analyzed.All included patients were younger than or equal to 40 years of age at the time ofdiagnosis，had a clear time of death，and were confirmed to be primary lung cancer by pathology or cytology.Kaplan?Meier survivalcurves were plotted and log?rank tests were performed to obtain the significant influential factors，which were later drawn into the Cox proportional hazards regression model for comparing independent impact factors on patient survivals.Results The age of onset was(34.5±5.6)years，the age range was 18?40 years，and the male?to?female ratio was 1.13∶1.The most common pathological type was adenocarcinoma，and the majority of patients were diagnosed with advanced TNM(Tumor lymph Node Metastasis) stage.Among all patients cough(55.8%)were revealed to be the most common pathological type and symptoms.Among the distant metas? tases，bone(51.8%)is the most common and fiberbronchoscope examination(37.1%)is the most widely applied diagnostic ap?proach.Univariate analysis showed the survival time of young patients with lung cancer was significantly associated with smokinghistory(P＝0.031)，pathologic type(P＝0.040)and TNM stage(P＜0.001).Multivariate analysis showed that TNM stage(P＜0.001)and pathologic type(P＝0.004)were independent prognostic factors of young lung cancer patients.Conclusion Adenocar? cinoma and advanced stage were hallmarks of young lung cancer patients.Early detection will benefit young lung cancer patients. |
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