| 薛俊麟,孟庆辉,肖鹏,等.Capicua在肿瘤中的研究进展[J].安徽医药,2020,24(9):1697-1700. |
| Capicua在肿瘤中的研究进展 |
| Research progress on the role of Capicua in neoplasm |
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| DOI：10.3969/j.issn.1009-6469.2020.09.001 |
| 中文关键词: 肿瘤 /病因学 高迁移率族蛋白质类 受体蛋白质酪氨酸激酶类 同源盒结构域蛋白质类 Capicua CIC-DUX4 RTK信号通路 多瘤病毒增强子激活剂 3(PEA3) |
| 英文关键词: Neoplasms/etiology High mobility group proteins Receptor protein-tyrosine kinases Homeodomain proteins |
| 基金项目:吴阶平医学基金会(320.6750.16018) |
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| 中文摘要: |
| Capicua(CIC)是一种在生物进化过程中高度保守的高迁移率族蛋白( high mobility group-box，HMG-box)转录因子，可特异性识别 T(G/C)AATG(A/G)A序列，并抑制靶基因的表达。作为受体酪氨酸激酶( RTK)信号通路的下游效应因子， CIC可参与多种发育决定。 CIC突变以及染色体易位相关的 CIC基因融合可造成多种人类疾病，且与肿瘤关系尤为密切，如少突胶质瘤、肺癌和尤文肉瘤等。本课题组现就 CIC在肿瘤的最新研究进展作一综述，揭示其在信号传导、肿瘤发生及新型治疗中的重要作用。 |
| 英文摘要: |
| Capicua(CIC)is a high mobility group-box(HMG-box)transcription factor that is well conserved in the process of bio- logical evolution.It can specifically recognize T(G/C)AATG(A/G)A sequence and inhibit the expression of target gene.CIC controlsmultiple developmental decisions acting as downstream of Receptor Tyrosine Kinase(RTK)signaling.CIC mutation as well as chro-mosomal translocation-associated gene fusions are involved in multiple human diseases especially neoplasm，such as oligodendrogli- oma，lung carcinoma，Ewing’s sarcoma.This article is aimed to reveal the significant role of CIC in signal transduction，carcinogene- sis and developing novel therapies by reviewing the latest research progress of CIC in neoplasm. |
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