| 胡耀,谭昀,桂绍涛,等.高血脂病人载脂蛋白E基因多态性与心肌梗死相关性[J].安徽医药,2020,24(9):1753-1756. |
| 高血脂病人载脂蛋白E基因多态性与心肌梗死相关性 |
| ApoE gene polymorphism in hyperlipidemia patients and its correlation with myocardial infarction |
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| DOI：10.3969/j.issn.1009-6469.2020.09.014 |
| 中文关键词: 高脂血症 载脂蛋白 E类 多态现象，遗传 心肌梗死 |
| 英文关键词: Hyperlipidemias Apolipoproteins E Polymorphism,genetic Myocardial infarction |
| 基金项目:江西省健康委员会项目( 20195014) |
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| 中文摘要: |
| 目的探寻载脂蛋白 E(ApoE)基因多态性与心肌梗死之间的相关性。方法选取 2017年 1—6月江西省人民医院 685例高脂血症病人进行 ApoE基因型检测(其中心肌梗死病人 53例，非心肌梗死病人 632例)。随后进行统计学分析。结果检测出三组 ApoE型: E2表型组( E2/E2，E2/E3)、 E3表型组( E3/E3，E3/E4)、 E4表型组( E2/E4，E4/E4)。其中， E3表型组占大多数(440例)。同时，心肌梗死组 E2表型组、 E3表型组与非心肌梗死组对比，差异无统计学意义( P＞0.05)；而 ApoE E4组等位基因(171人)与心肌梗死密切相关联( E2/E4:13.5%比 4.33%，E4/E4:11.23%比 2.18%，均 P＜0.05)。结论 ApoE E3基因型占大多数， ApoE E4等位基因与心肌梗死密切相关。 |
| 英文摘要: |
| Objective To observe the correlation between apolipoprotein E(ApoE)gene polymorphism and myocardial infarction(AMI).Methods A total of 685 patients with hyperlipidemia(53 patients were MI and 632 patients were non-MI)in Jiangxi Pro- vincial People’s Hospital Affiliated to Nanchang University from January to June 2017 were selected for ApoE genotyping.Statisti-cal analysis was then performed.Results Three genotypes of ApoE were detected，namely E2 genotype(E2/E2，E2/E3)E3 geno- type(E3/E3，E3/E4)and E4 genotype(E2/E4，E4/E4)，of which E3/E3 genotype accounted for the majority(440 persons).，In the meantime，there was no significant difference between E2 genotype and E3 genotype in myocardial infarction group and non-myocar-dial infarction group.ApoE E4 allele(171 persons)( E2/E4:13.5% vs. 4.33%，E4/E4:11.23% vs. 2.18%，both P＜0.05)was close- ly related to myocardial infarction.Conclusion ApoE E3 genotype accounts for the majority among 685 patients.ApoE E4 allele is closely related to myocardial infarction. |
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