| 赵晓玲,金丹群,朱玉林.小儿耐甲氧西林与甲氧西林敏感金黄色葡萄球菌感染病例临床特征及耐药性对比分析[J].安徽医药,2020,24(9):1846-1849. |
| 小儿耐甲氧西林与甲氧西林敏感金黄色葡萄球菌感染病例临床特征及耐药性对比分析 |
| The comparison of clinical features and drug resistance between MRSA and MSSA infections in children |
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| DOI：10.3969/j.issn.1009-6469.2020.09.039 |
| 中文关键词: 耐甲氧西林金黄色葡萄球菌 致病力 微生物敏感性试验 婴儿 儿童 临床特征 |
| 英文关键词: Methicillin-resistant staphylococcus aureus Pathogenicity Microbial sensitivity tests Infant Child Clinical features |
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| 中文摘要: |
| 目的探讨小儿耐甲氧西林金黄色葡萄球菌( MRSA)和甲氧西林敏感金黄色葡萄球菌( MSSA)感染病例临床特征与耐药性。方法选取 2014年 6月至 2016年 1月期间安徽省儿童医院就诊的 264例金黄色葡萄球菌感染病儿，根据《全国临床检验操作规程(第 3版)推荐的抗生素药敏试验结果分为 MRSA病例组 149例， MSSA病例组 115例，收集两组病例的人口学资料、血常规检测结果、 C》反应蛋白( CRP)值、感染部位和耐药性检测结果等数据并进行对比分析。结果 MRSA组住院天数为(13.8±10.2)d，MSSA组为( 11.1±10.4)d；MRSA组 CRP值为( 48.4±56.9)mg/L，MSSA组为( 30.0±41.5)mg/L；MRSA组败血症发生率为 27.5%，MSSA组为 13.0%；MRSA组呼吸道感染率为 13.4%，MSSA组为 4.3%；MRSA组在住院天数、 CRP值、败血症发生率和呼吸道感染率高于 MSSA组，差异有统计学意义(P＜0.05)； MRSA组对氨苄青霉素舒巴坦、阿莫西林 /克拉维酸钾、头孢曲松、克林霉素、红霉素、四环素、复方磺胺甲唑和左氧氟沙星的耐药性高于 MSSA组( P＜0.05)。结论小儿 MRSA病例在败血症发生率、呼吸道感染、 CRP值和耐药性上高于 MSSA病例。 |
| 英文摘要: |
| Objective To analyze the clinical characteristics and drug resistant between the cases of Methicillin-Resistant Staphylo- coccus Aureus(MRSA)and Methicillin Sensitive Staphylococcus Aureus(MSSA).Methods A total of 264 staphylococcus aureus infection cases in Anhui Provincial Children’s Hospital from June 2014 to January 2016 were recruited and divided into 149MRSA cases and 115 MSSA cases according to the antibiotic susceptibility test which was recommended by the Clinical and Labo-ratory Standards Institute.The data of demographic features，blood routine examination，C-reactive protein，infection position，and drug sensitive test were collected and compared between the two groups.Results The lengthen of stay in MRSA group was(13.8±10.2)days，while(11.1±10.4)days of MSSA group.The CRP value of MRSA group was(48.4±56.9)mg/L，and that of the MSSA group was(30.0±41.5)mg/L.The incidence of septicemia in MRSA group was 27.5%，while MSSA group was 13.0%.The incidenceof respiratory infection was 13.4% in MRSA group and 4.3% in MSSA group.There were significant differences in the averagelength of stay，CRP value，septicemia and respiratory infection between MRSA and MSSA group(P＜0.05).The MRSA group was with higher drug-resistant rate than MSSA group among ampicillin，amoxycillin-clavulanic acid，ceftriaxone，clindamycin，erythromy- cin，tetracycline，trimethoprim/sulfamethoxazole and levofloxacin(P＜0.05).Conclusion The incidence of sepsis，respiratory tract infection，CRP and drug resistance in children with MRSA were significant higher than those with MSSA. |
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