| 张青,李志云.药用炭对维持性血液透析病人肾功能、钙磷失衡的影响[J].安徽医药,2020,24(9):1859-1862. |
| 药用炭对维持性血液透析病人肾功能、钙磷失衡的影响 |
| Effects of medicinal charcoal tablets on renal function and imbalance of calcium and phosphorus in patients with maintenance hemodialysis |
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| DOI：10.3969/j.issn.1009-6469.2020.09.042 |
| 中文关键词: 肾功能衰竭，慢性/治疗 血液透析滤过 炭 司维拉姆 维持性血液透析 高磷血症 肾性骨病 |
| 英文关键词: Kidney failure,chronic/therapy Hemodiafiltration Charcoal Sevelamer Maintenance hemodialysis Hyper- phosphatemia Renal osteopathia |
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| 中文摘要: |
| 目的探讨药用炭对维持性血液透析病人肾功能、钙磷失衡的影响。方法 2017年 1月至 2018年 1月在泰安市第四人民医院进行维持性血液透析的 100例病人，按随机数字表法分为研究组和对照组，每组 50例。对照组口服盐酸司维拉姆。研究组在口服盐酸司维拉姆治疗的基础上，口服药用炭(爱西特片)。治疗时间均为 5个月。分别于基线、治疗后 1个月、 3个月、 5个月时空腹采集静脉血。采用化学法测定血中钙、磷、尿素氮、血肌酐、血浆白蛋白( Alb)、 β2微球蛋白( β2-MG)、 I型前胶原氨基端延长肽( PINP)、 β-胶原降解产物( β-CTX)、骨钙素水平，计算钙磷乘积。采用放射免疫法检测血清全段甲状旁腺激素 |
| 英文摘要: |
| Objective To investigate the effect of medicinal charcoal tablets on renal function and calcium and phosphorus imbal-ance in patients with maintenance hemodialysis.Methods From January 2017 to January 2018，100 patients undergoing mainte- nance hemodialysis in at the Fourth People’s Hospital of Tai’an were randomly divided into study group and control group accord- ing to the random number table method，with 50 patients in each group.The control group received oral sevelamer hydrochloride.Onthe basis of oral sevelamer hydrochloride treatment，the study group took Aixit medicinal carbon tablets orally.The treatment dura-tion is 5 months.Venous blood was collected on an empty stomach at baseline，1 month，3 months and 5 months after treatment，re-spectively.Chemical methods were used to determine blood calcium，phosphorus，urea nitrogen，blood creatinine，plasma albumin(Alb)β2 microglobulin(β2-MG)type I procollagen amino terminal extension peptide(PINP)β-collagen degradation products(Β-CTX)，，the level of osteocalcin，Che，mical methods were used to the levels of blood calcium(Ca)，phosphorus(P)，urea nitrogen(BUN)，serum creatinine(Scr)plasma albumin(Alb)β2 microglobulin(β2-MG)，typeIprocollage，n amino terminal elongation peptide(PINP)，β-collagendegrad，ation product(β-CTX)，，osteocalcin and the product of calcium and phosphorus was calculated.Radioimmunoassay was used to detect the level of serum parathyroid hormone(iPTH).The adverse reactions of the two groups dur- ing the treatment were statistically analyzed.Results The level of Calcium，phosphorus，calcium and phosphorus product of the study group 5 months after treatment:(4.35±0.42)mmol2/L2 vs.(4.74±0.38)mmol2/L2，iPTH，urea nitrogen 5 months after treat- ment:(17.50±1.78)mmol/L vs.(19.54±1.78)mmol/L，blood creatinine 5 months after treatment:(715.60±67.41)μmol/L vs. |
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