文章摘要
李娜,唐志红,田永明.耐碳青霉烯鲍曼不动杆菌医院感染预后相关危险因素的 Meta分析[J].安徽医药,2020,24(10):1920-1926.
耐碳青霉烯鲍曼不动杆菌医院感染预后相关危险因素的 Meta分析
Meta?analysis of the prognosis risk factors for nosocomial infection in carbapenem?resistant acinetobacter baumannii
  
DOI:10.3969/j.issn.1009?6469.2020.10.003
中文关键词: 鲍氏不动杆菌/致病力  耐碳青霉烯鲍曼不动杆菌  医院感染  预后  危险因素  Meta分析
英文关键词: Acinetobacter baumannii/pathogenicity  Carbapenem?resistant acinetobacter baumannii  Nosocomial infection  
基金项目:
作者单位E-mail
李娜 四川大学华西医院重症医学科四川成都 610041  
唐志红 四川大学华西医院重症医学科四川成都 610041  
田永明 四川大学华西医院重症医学科四川成都 610041 arrontian@163.com 
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中文摘要:
      目的探索耐碳青霉烯鲍曼不动杆菌(Carbapenem?resistant Acinetobacter baumannii,CRAB)医院感染预后相关的危险因素,以期能够指导临床防治 CRAB医院感染,减少 CRAB感染病人的死亡风险。方法计算机检索检索万方、中国知网(CNKI)、维普(VIP)、 CBM、EMbase、PubMed、OVID,以及医学网站中公开发表的文献,检索时限截至 2019年 5月 31日,采用 State13进行 Meta分析。结果共纳入 32篇文献(英文 26篇,中文 6篇)其中存活组 1 607例病人,死亡组 1 372例病人。在纳入的 24项研究因素中,有 15项研究因素差异有统计学意义(P<0.05)年龄,(MD=0.19,95%CI:0.08~0.30,P<0.01)、 APCHE II评分(MD=0.48,95%CI:0.06~0.91,P=0.03)、入住 ICU(OR=1.91,9,5%CI:1.12~3.26,P=0.02)、发生过休克(OR=4.28, 95%CI:1.05~17.49,P=0.04)、脓毒性休克(OR=8.36,95%CI:3.71~18.82,P<0.01)、肾功能损伤(OR=1.57,95%CI:1.19~2.07, P<0.01)、糖尿病(OR=1.31,95%CI:1.03~1.68,P=0.03)、肿瘤(OR=1.56,95%CI:1.02~2.37,P=0.04)、肝脏疾病(OR=1.93, 95%CI:1.25~3.00,P<0.01)、深静脉置管(OR=2.02,95%CI:1.56~2.61,P<0.01)、留置导尿管(OR=2.53,95%CI:1.66~3.84,P<0.01)、留置鼻饲管(OR=1.79,95%CI:1.21~2.65,P<0.01)、机械通气(OR=3.17,95%CI:2.34~4.29,P<0.01)、使用激素(OR=5.46,95%CI:3.12~9.56,P<0.01)、免疫抑制(OR=2.73,95%CI:1.82~4.1,P<0.01)。结论基础疾病严重程度和侵入性操作相关因素是耐碳青霉烯鲍曼不动杆菌医院感染病人高死亡率的主要危险因素,可有助于临床医务人员采取适当的防控措施,降低耐碳青霉烯鲍曼不动杆菌感染病人的死亡率。
英文摘要:
      Objective To explore the risk factors associated with prognosis of carbapenem?resistant Acinetobacter baumannii(CRAB)by meta?analysis,so as to guide clinical prevention and treatment of CRAB and reduce the risk of death in patients.Meth? ods We searched Wanfang,CNKI,VIP,CBM,EMBASE,PubMed,OVID and medical websites by computer.The retrieval deadline was May 31 2019.Meta?analysis was performed by the statistical software Stata13.Results 32 studies were enrolled(26 inEnglish, 6 in Chinese).There were 1607 patients in survival group and 1372 patients in death group.Of the 24 included study factors,15 showed statistically significant differences(P<0.05):Age(MD=0.19,95%CI:0.08-0.30,P<0.01),APCHE II score(MD=0.48, 95%CI:0.06-0.91,P=0.03)ICU admission(OR=1.91,95%CI:1.12?3.26,P=0.02),shock(OR=4.28,95%CI:1.05?17.49,P=0.04),septic shock(OR=8.365%CI:3.71?18.82,P<0.01),impaired renal function(OR=1.57,95%CI:1.19?2.07,P<0.01),dia?betes(OR=1.31,95%CI:1.03?1.68,P=0.03),tumour(OR=1.56,95%CI:1.02?2.37,P=0.04),liver disease(OR=1.93,95%CI:9,1.25?3.00,P<0.01),deep venous puncture(OR=2.02,95%CI:1.56?2.61,P<0.01),indwelling catheter(OR=2.53,95%CI:1.66?3.84,P<0.01)indwelling gastric tube(OR=1.79,95%CI:1.21?2.65,P<0.01),mechanical ventilation(OR=3.17,95%CI:2.34?4.29,P<0.01)se of hormones(OR=5.46,95%CI:3.12?9.56,P<0.01),use of immunosuppressants(OR=2.73,95%CI:1.82? u,4.1,P<0.01) clusion The severity of underlying diseases and related factors of invasive procedure are the main risk factors for.Con,high mortality in CRAB nosocomial infection patients.It can help clinicians to take appropriate preventive and control measures to reduce the mortality of CRAB infected patients.
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