| 周高礼,赵凤朝.尼美舒利辅助全膝置换术治疗膝骨关节炎的疗效及对高迁移率簇蛋白 B1、钙结合蛋白(S100A12)的短期影响[J].安徽医药,2020,24(10):1970-1974. |
| 尼美舒利辅助全膝置换术治疗膝骨关节炎的疗效及对高迁移率簇蛋白 B1、钙结合蛋白(S100A12)的短期影响 |
| Effect of nimesulide?assisted total knee arthroplasty on knee osteoarthritis and its influence on HMGB1 and S100A12 |
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| DOI：10.3969/j.issn.1009?6469.2020.10.013 |
| 中文关键词: 骨关节炎，膝 关节成形术，置换，膝 S100蛋白质类 尼美舒利 治疗结果 高迁移率簇蛋白 B1 |
| 英文关键词: Osteoarthritis,knee Arthroplasty,replacement,knee S100 proteins Nimesulide Treatment outcome High |
| 基金项目:江苏省科技厅社会发展重点项目(BE2016642) |
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| 目的探讨尼美舒利辅助全膝置换术治疗膝骨关节炎的治疗效果及其对病人关节液高迁移率簇蛋白 B1(HMGB1)、钙结合蛋白 S100A12的影响。方法选取 2016年 2月至 2018年 11月在天门市第一人民医院接受治疗的 96例膝骨关节炎病人作为研究对象，应用随机数字表法分为对照组 48例和联合组 48例。两组病人均行人工全膝关节置换术治疗，联合组病人同时给予尼美舒利片口服， 0.1克/次， 2次/天。评价并比较两组病人的治疗效果和治疗前后的膝关节美国特种外科医院功能评分(HSS)、关节活动度、视觉模拟评分(VAS)检测并比较两组病人治疗前后血清白细胞介素 1(IL?1)、白细胞介素 1(IL?6)、 C反应蛋白(CRP)及关节液 HMGB1、S100A12水平，变化情况。结果术后末次随访评价两组病人的疗效，对照组治疗总有效率为 |
| 英文摘要: |
| Objective To investigate the therapeutic effect of nimesulide?assisted total knee arthroplasty(TKA)on knee osteoar? thritis and its effect on high mobility cluster protein B1(HMGB1)and calcium binding protein S100A12 in synovial fluid.Meth? ods Ninety?six cases of knee osteoarthritis patients who received treatment inTianmen First People′ s Hospital from February2016 to November 2018 were selected as the research objects.They were randomly assigned into the control group(48 cases)and the combined group(48 cases)using the random number table method.Patients in the two groups were treated with artificial totalknee arthroplasty.The combined group was given nimesulide tablets orally at the same time，0.1 g/time，2 times/day.The therapeutic effect of the two groups，the scores of hospital for special surgery(HSS)，joint mobility and visual analogue scale(VAS)before and after treatment were evaluated and compared.The serum interleukin(IL)?1，IL?6，C?reactive protein(CRP)and joint of the two groups before and after treatment，changes of liquid HMGB1 and S100A12 levels were compared.Results The total effective rate of the two groups was 79.17%(38/48)in the control group and 93.75%(45/48)in the combined group.The total effective rate of the combined group was significantly higher than that of the control group(P＜0.05)； the HSS score，activity of the two groups were significantly increased，and the VAS score was significantly decreased.There were significant differences in HSS score［(93.05±7.20)points vs.(82.63±7.96)points，VAS score［(2.48±0.51)points vs.(4.34±0.85)points］and knee joint activity［(107.62±8.80)° vs.(102.82±10.39)°］between the two groups after treatment(P＜0.05)； serum IL?1，IL ?6，CRP，synovial fluid HMGB1 and S100A12 of patients in the two groups before treatment were significantly different(P＞0.05)； serum IL?1，IL?6，CRP，synovial flu? id HMGB1，and S100A12 of patients after treatment were significantly lower than before treatment，and there were significant differ? ences in serum inflammatory indexes IL?1［(73.39±8.95)ng/L vs.(89.74±9.82)ng/L］，IL?6［(109.65±26.33)ng/L vs.(173.40±33.71) ng/L］，CRP［(8.72±4.46)mg/L vs.(14.50±7.72)mg/L］joint fluid HMGB1［(3.85±1.16)ρg/mL vs.(5.33±1.97)ρg/mL］，and S100A12［(8.26±4.12)ng/mL vsween the combined group and the control group after treatment(P＜(11.09±5.88)ng/mL］bet，0.05).Conclusion Nimesulide?assisted total knee arthroplasty can further improve the curative effect of surgical treatment for knee osteoarthritis，help to significantly improve clinical symptoms and knee function，reduce serum levels of inflammatory factorsand levels of HMGB1 and S100A12 in synovial fluid.Detection of HMGB1 and S100A12 in synovial fluid can provide reference forclinical treatment of knee osteoarthritis. |
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