| 陈勇,冯艺,赵彩霞,等.子宫腺瘤样瘤 67例临床病理分析[J].安徽医药,2020,24(10):1992-1995. |
| 子宫腺瘤样瘤 67例临床病理分析 |
| Clinicopathologic an analysis of 67 cases of uterine adenomatoid tumors |
| |
| DOI：10.3969/j.issn.1009?6469.2020.10.019 |
| 中文关键词: 腺瘤样瘤 子宫肿瘤 临床病理特征 上皮 角蛋白 5 角蛋白 6 唾液糖蛋白类 免疫组织化学 |
| 英文关键词: Adenomatoid tumors Uterine neoplasms Clinicopathologic characteristics Epithelium Keratin?5 Keratin?6 Sialoglycoproteins Immunohistochemical staining |
| 基金项目: |
|
| 摘要点击次数: 1533 |
| 全文下载次数: 512 |
| 中文摘要: |
| 目的探讨子宫腺瘤样瘤(Adenomatoid Tumors，ATs)临床病理特征、免疫表型、鉴别诊断、治疗及预后。方法回顾性分析安徽医科大学附属妇幼保健院病理科 2012年 1月至 2018年 1月 67例子宫 ATs的临床特点、病理形态学及免疫表型特征，并复习相关文献。结果病人均为女性，年龄范围 24～64岁，中位年龄 39岁。肿瘤位于子宫浆膜下或肌壁间，其中 66例呈结节状(直径 1.0～8.0 cm)，平均直径 2.7 cm，1例呈巨大囊实性(直径 12.0 cm)。肿块切面灰白，质韧，类似平滑肌瘤，与周围组织界限不清。肿瘤由大小不等的管腔或乳头状结构构成，被覆扁平或立方上皮细胞，呈单个或巢状分布于平滑肌组织之间。所有病例肿瘤细胞均无明显异型性，核分裂象罕见。免疫组织化学结果显示肿瘤细胞角蛋白广谱抗体(CKAE1/AE3)、钙网膜蛋白(Calretinin)、跨膜唾液酸糖蛋白(D2?40)、细胞角蛋白(CK5/6)的阳性率分别为 100.0%(67/67)、 100.0%(67/67)、 100.0%(67/ 67)、 19.4%(13/67)肿瘤增殖抗原(Ki?67)增殖指数低，约 1%～5%之间，高度糖基化的 i型跨膜糖蛋白(CD34)不表达。结论子宫 ATs是一种少见的，间叶来源的良性肿瘤，但组织学特征多样，尤其出现腺腔样结构难与腺癌相鉴别，结合镜下形态特点及免疫组化有助于提高诊断准确率，治疗以手术切除为主。 |
| 英文摘要: |
| Objective To investigate the clinicopathologic characteristics，immunophenotypes，differential diagnosis，treatment and prognosis of uterine adenomatoid tumors(ATs).Methods Clinicopathologic findings and immunophenotypes of 67 cases of uterine ATs in the Department of Pathology，Affiliated Maternal and Child Health Hospital of Anhui Medical University from January 2012to January 2018 were retrospectively analyzed，and the relevant literatures were also reviewed.Results The patients were all fe? male，ranging in age from 24 to 64 years，with a median age was 39 years.Most of uterine ATs located in subserous membrane ormuscle intramural.The 66 cases of uterine ATs ranged from 1.0 cm to 8.0 cm with an average diameter of 2.7 cm and 1 large cystictumor was 12.0cm in diameter.Macroscopically，the tumor had a grayish white cut surface with a firm texture like leiomyoma，but the margin was not clear.Tumors are composed of lumens or papillary structures of varying sizes，covered with flat or cubic epitheli? al cells，distributed in single or nested form among smooth muscle tissues.The tumor cells with no atypia and mitotic figures wererare.Immunohistochemistry staining showed that the positive rates of CKAE1/AE3，Calretinin，D2?40 and CK5/6 in tumor cells were 100.0%(67/67)100.0%(67/67)100.0%(67/67)and 19.4%(13/67)，respectively.The tumor proliferation antigen(Ki?67)index waslow， transmembrane glycoprotein(CD34)is not expressed.Conclusions Uterine ATs is a rare benign tumor originating from mesenchymal tissue.However, the histologic characteristics are diverse, especially the about1%?，5%.thehighlygly，cosylatedi?type，adenoid structure is difficult to distinguish from adenocarcinoma.The morphological features with immunohistochemical staining canimprove the diagnostic accuracy.Surgical resection is the mainly treatment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
