| 宋哲,李伟,贾楠,等.多层螺旋 CT灌注参数与直肠癌临床病理指标的相关性[J].安徽医药,2020,24(10):1995-1998. |
| 多层螺旋 CT灌注参数与直肠癌临床病理指标的相关性 |
| Correlation between perfusion parameters of multi?slice CT and clinicopathological parameters of rectal cancer |
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| DOI：10.3969/j.issn.1009?6469.2020.10.020 |
| 中文关键词: 直肠肿瘤 体层摄影术，螺旋计算机 癌胚抗原 CA?19?9抗原 病理分期 灌注参数 |
| 英文关键词: Rectal neoplasms Tomography,spiral computed Carcinoembryonic antigen CA?19?9 antigen Pathological stage Perfusion parameters |
| 基金项目:沧州市重点研发计划指导项目(183302033) |
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| 中文摘要: |
| 目的探究多层螺旋 CT(multislice CT，MSCT)灌注参数与直肠癌临床病理分期及胰岛素样生长因子 ?1(insulin like growth factor?1，IGF?1)、癌胚抗原(carcinoembryonic antigen，CEA)、糖类抗原 19?9(Carbohydrate antigen19?9，CA19?9)指标相关性。方法选取 2015年 2月至 2018年 12月沧州市中心医院收治的 60例直肠癌病人，依据病理结果进行 TNM分级，比较各期病人病灶感兴趣区多层螺旋 CT(multislice CT，MSCT)灌注参数［血容量(blood value，BV)、血流量(blood flow，BF)、达峰时间(time to top，TTP)、表面通透性(permeability surface，PS)］，入院时 IGF?1、CEA、CA19?9水平，采用 person或者 spearman相关性分析检测灌注参数与肿瘤标记物的相关性。结果 T4期 BF(54.35±16.25)mL·min-1·100 g-1显著低于 T1~T2期(89.48±27.34) mL·min-1·100 g-1和 T3期(67.13±22.34)mL·min-1·100 g-1，TTP(29.13±8.35)s和 PS(59.25±15.98)mL·min-1·100 g-1显著高于 T1~T2期［(17.62±5.34)s，(31.71±7.82)mL·min-1·100 g-1］和 T3期［(26.78±6.23)s，(47.69±11.21)mL·min-1·100 g-1P＜0.05］；直肠癌 T分期与 BF呈明显负相关，与 TTP和 PS呈明显正相关(P＜0.05)。 T4期 IGF?1，CEA和 CA19?9显著高于 T1~T2期，和 T3期(P＜0.05)。病灶 BF与 IGF?1、CEA、CA19?9呈明显负相关， TTP、PS与 IGF?1、CEA、CA19?9呈明显正相关(P＜0.05)。结论直肠癌病灶 MSCT灌注参数及 IGF?1，CEA，CA19?9水平与 TNM分期有良好相关性。 |
| 英文摘要: |
| Objective To investigate the correlation between perfusion parameters of multi?slice CT (MSCT) and the clinicopatho?logical stages of rectal cancer as well as insulin like growth factor?1 (IGF?1)，carcinoembryonic antigen (CEA) and glycine antigen 19?9 (CA19?9).Methods Sixty patients with rectal cancer admitted to Cangzhou City Central Hospital from February 2015 to De? cember 2018 were selected，and TNM classification was performed according to pathological findings.Perfusion parameters of MSCT［blood value (BV)，blood flow(blood flow，BF)，time to top (TTP)，permeability surface (PS)］in the area of interest of the foci of pa? tients at each stage，IGF?1，CEA，CA19?9 levels at admission were compared，and the correlation between perfusion parameters and tumor markers were analyzed by Person or Spearman correlation analysis.Results BF(54.35±16.25)mL·min-1·100 g-1 of stage T4 was significantly lower than that of stage T1~T2(89.48±27.34) mL·min-1·100 g-1 and T3 (67.13±22.34)mL·min-1·100 g-1，and TTP (29.13±8.35)s and PS (59.25±15.98)mL·min-1·100 g-1 were significantly higher than those in T1 to T2 (17.62±5.34)s，(31.71±7.82) mL·min-1·100 g-1 and T3 (26.78±6.23)s，(47.69±11.21)mL·min-1·100 g-1(P＜0.05)； T stage of rectal cancer was significantly nega? tively correlated with BF，and significantly positively correlated with TTP and PS (P＜0.05).IGF?1，CEA and CA19?9 of T4 stage were significantly higher than those of T1~T2 and T3 stage (P＜0.05).Focal BF was significantly negatively correlated with IGF?1， CEA，and CA19?9，and TTP and PS were significantly positively correlated with IGF?1，CEA，and CA19?9 (P＜0.05).Conclusion The MSCT perfusion parameters and the levels of IGF?1，CEA，CA19?9 in rectal cancer lesions are well correlated with TNM stag? ing. |
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