| 梁利红.血清及肺泡灌洗液 γ干扰素、血栓素和可溶性 B7?H3在难治性肺炎支原体肺炎中的鉴别诊断价值分析[J].安徽医药,2020,24(10):2054-2058. |
| 血清及肺泡灌洗液 γ干扰素、血栓素和可溶性 B7?H3在难治性肺炎支原体肺炎中的鉴别诊断价值分析 |
| Diagnostic value of serum and alveolar lavage fluid interferon?γ， thrombin and soluble B7?H3 in the treatment of refractory mycoplasma pneumoniae |
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| DOI：10.3969/j.issn.1009?6469.2020.10.035 |
| 中文关键词: 肺炎，支原体/诊断 支气管肺泡灌洗液 血清 γ干扰素 血栓素 可溶性 B7?H3 儿童 |
| 英文关键词: Pneumonia,mycoplasma/ diagnosis Bronchoalveolar lavage fluid Serum Interferon?γ Thromboxane Solub? leB7?H3 Child |
| 基金项目:2018年度河南省医学科技攻关计划(联合共建项目)(2018020674) |
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| 中文摘要: |
| 目的探究血清及肺泡灌洗液 γ干扰素(IFN?γ)、血栓素(TXB2)、可溶性 B7?H3(sB7?H3)在难治性肺炎支原体肺炎(RM? PP)病儿中的表达水平及鉴别诊断价值。方法选择 2017年 2月至 2019年 3月于郑州大学附属儿童医院住院治疗的 80例 RMPP病儿、 80例普通支原体肺炎(MPP)病儿及 50例查体健康儿童作为研究对象，分别纳入 RMPP组、 MPP组及对照组。收集临床症状，测定血清及肺泡灌洗液 IFN?γ、TXB2和 sB7?H3水平。结果 RMPP组病儿肺部呼吸音减低、肺实变、胸腔积液、黏膜糜烂、黏液栓形成等发生率显著高于 MPP组(P＜0.05)； RMPP组、 MPP组病儿血清 IFN?γ［(895.63±212.96)、(624.85±158.96) pg/mL］、 TXB2［(289.28±89.56)、(195.17±79.63)pg/mL］和 sB7?H3［(466.71±127.45)、(312.48±105.71)pg/mL］水平显著高于对照组［(104.12±31.02)、(35.85±12.45)、(44.15±15.74)pg/mL］(P＜0.05)，RMPP组血清各指标水平高于 MPP组(P＜0.05)； RMPP组病儿肺泡灌洗液中 IFN?γ［(89.46±34.12)、(45.78±10.27)pg/mL］、TXB2［(88.45±32.78)、(54.17±17.48)pg/mL］和 sB7?H3 |
| 英文摘要: |
| Objective To investigate the expression levels of interferon?γ(IFN?γ)，thromboxane(TXB2)and soluble B7?H3(sB7?H3) in serum and bronchoalveolar lavage fluid of children with refractory Mycoplasma pneumoniae pneumonia(RMPP) and their diagnostic value.Methods Eighty children with RMPP who were hospitalized in Children’s Hospital Affiliated to Zheng?zhou University from February 2017 to March 2019 and 80 children with common MPP were selected as subjects.They were en?rolled in RMPP group and MPP group，respectively.Clinical symptoms were collected，and levels of IFN?γ，TXB2 and sB7?H3 in serum and bronchoalveolar lavage fluid were determined.Results The incidence rates of reduced lung breath sounds，lung consoli? dation，pleural effusion，mucosal erosion and mucus plug formation were significantly higher in RMPP group than in MPP group(P＜0.05).The levels of IFN?γ［(895.63±212.96)(624.85±158.96)pg/mL］TXB2［(289.28±89.56)，(195.17±79.63)pg/mL］ and sB7?H3［(466.71±127.45)P group and MPP group were significantly higher than those in control group［(10412±31.02)，(35.85±12.45)，(44.15±15.74)pg/mL］(P＜0.05).The serum levels of RMPP group were higher than those in MPP group(P＜0.05).Levels of IFN?γ［(89.46±34.12)(45.78±10.27)pg/mL］，TXB2［(88.45± (312.48±105.71)，pg/mL］inseruminRMP，32.78)(54.17±17.48)pg/mL］and sB7?H3［(142.51±44.78)bronchoalveolar lavage fluid of RMPP e significantly higher than those in MPP group(P＜05).Serum levels of IFN?γ and sB7?H3 were correlated with the occurrence of pleural effusion and lung consolidation(P＜0.05).Levels of serum TXB2 and IFN?γ，TXB2 and sB7?H3 in bron? choalveolar lavage fluid were correlated with the occurrence of reduced lung breath sounds，lung consolidation，pleural effusion (107.48±34.71)pg/mL］in，groupwer，.0，and mucus plug formation(P＜0.05).ROC curve analysis showed that the area under the curve of TXB2 in bronchoalveolar la? vage fluid was the largest，and the diagnostic cut?off value was 68.59 pg/mL.The diagnostic sensitivity and specificity were 85.0% and 78.7%，respectively.Conclusion Compared with children with MPP，levels of IFN?γ，TXB2 and sB7?H3 are significantly in?creased in serum and bronchoalveolar lavage fluid of children with RMPP.The diagnostic efficiency of TXB2 in bronchoalveolar la?vage fluid is the highest. |
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