| 魏旭明,张寒雪,王宁,等.舍曲林对原发性高血压合并焦虑抑郁病人血清 S100B蛋白、心肌营养素 1及血压的影响[J].安徽医药,2020,24(10):2075-2078. |
| 舍曲林对原发性高血压合并焦虑抑郁病人血清 S100B蛋白、心肌营养素 1及血压的影响 |
| Effect of sertraline on serum S100B protein，cardiotrophin?1 and blood pressure in patients with essential hypertension complicated with anxiety and depression |
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| DOI：10.3969/j.issn.1009?6469.2020.10.040 |
| 中文关键词: 高血压/并发症 焦虑 抑郁 舍曲林 S100蛋白质类 心肌营养素 ?1 |
| 英文关键词: Hypertension/complications Anxiety Depression Serteraline S100B Cardiotrophin?1 |
| 基金项目:河南省高等学校重点科研项目(16B320018) |
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| 中文摘要: |
| 目的观察原发性高血压合并焦虑、抑郁病人应用舍曲林治疗对情绪、血清 S100B蛋白(神经组织蛋白质 S100)与心肌营养素 1(CT?1)及血压的影响。方法选取新乡医学院第二附属医院 2015年 12月至 2017年 6月收治的 106例原发性高血压合并焦虑、抑郁的病人为研究对象，退出 6例，将剩余 100例按随机数字表法分为对照组和观察组，所有病人均应用替米沙坦口服，观察组加用舍曲林口服，对照组加用相同剂型的安慰剂口服，持续治疗 1月。于治疗前后应用焦虑自评量表(SAS)及抑郁自评量表(SDS)对两组病人焦虑及抑郁症状进行评分，用动态血压仪测定两组病人治疗前后 24 h平均收缩压(24 h SBP)、 24 h平均舒张压(24 h DBP)、白昼平均收缩压(dSBP)、夜间平均收缩压(nSBP)、白昼平均舒张压(dDBP)及夜间平均舒张压(nDBP)并用酶联免疫吸附法检测血清 S100B、CT?1水平。结果观察组治疗后 SAS、SDS评分分别为(39.7±6.7)分、(38.4± 5.3)分，对照，组分别为(64.7±5.8)分、(58.1±4.9)分，观察组治疗后 SAS、SDS评分低于对照组(t＝19.965，19.369，均 P＜0.001)；观察组治疗后 24 h SBP、24hDBP、dSBP、nSBP、dDBP、nDBP分别为(118.2±6.7)、(78.3±6.6)、(124.1±7.3)、(112.3±6.1)、(82.5± 6.8)、(74.1±6.4)mmHg，对照组分别为(121.7±7.1)、(82.3±7.2)、(127.2±8.1)、(116.2±5.7)、(85.2±6.6)、(79.4±7.8)mmHg，观察组治疗后 24 h SBP、24 h DBP、dSBP、nSBP、dDBP、nDBP水平低于对照组(t＝2.535，P＜0.05；t＝2.896，P＜0.05；t＝2.010，P＜ 0.05；t＝3.303，P＜0.01；t＝2.012，P＜0.05；t＝3.714，P＜0.001)；观察组治疗后血清 S100B、CT?1分别为(60.6±13.4)pg/mL、(47.8±12.5)ng/L，对照组分别为(88.4±15.7)pg/mL、(56.7±11.2)ng/L，观察组治疗后血清 S100B、CT?1水平低于对照组(t＝7.468，3.751，均 P＜0.001)。结论舍曲林能有效改善原发性高血压合并焦虑、抑郁病人的焦虑、抑郁情绪，并辅助降低血压，从而血清 S100B、CT?1水平下降。 |
| 英文摘要: |
| Objective To observe the effects of sertraline on emotion，S100B protein，cardiotrophin?1(CT?1)and blood pressure in patients with essential hypertension combined with anxiety and depression.Methods One hundred and six patients with essentialhypertension combined with anxiety and depressionwho were admitted to the Second Affiliated Hospital of Xinxiang Medical Univer?sity from December 2015 to June 2017 were selected as the research objects，leaving 6 cases，the remaining 100 cases were ran?domly assigned into the control group and the observation groupaccording to random number table method.The observation groupwas treated telmisartan orally combined with sertraline，while the control group was treated telmisartan orally combined with place? bo of the same dosage form，the treatment lasted for 1 month.Self?rating Anxiety Scale(SAS)and Self?rating Depression Scale(SDS)were used to evaluate the anxiety and depressive symptoms of the two groups before and after treatment.The 24?hour meansystolic blood pressure(24?hour SBP)，24?hour mean diastolic blood pressure(24?hour DBP)，daytime mean systolic blood pres? sure(dSBP)，nighttime mean systolic blood pressure(nSBP)，daytime mean diastolic blood pressure(dDBP)and nighttime mean diastolic blood pressure(nDBP)were measured by ambulatory blood pressure meter before and after treatment.Serum S100B andCT?1 levels were measured by enzyme?linked immunosorbent assay.Results The SAS［(39.7+6.7)vs.(64.7+5.8)］and SDS［(38.4+ 5.3)vs.(58.1+4.9)］ scores after treatment in the observation group were significantly lower than those in the control group(t＝ 19.965，19.369，allP＜0.001).The 24?hour SBP［(118.2±6.7)mmHg vs.(121.7±7.1)mmHg］，24?hour DBP［(78.3±6.6)mmHg vs.(82.3±7.2)mmHg］，dSBP［(124.1±7.3)mmHg vs.(127.2±8.1)mmHg］，nSBP［(112.3±6.1)mmHg vs.(116.2±5.7)mmHg］，dDBP［(82.5±6.8)mmHg vs.(85.2±6.6)mmHg］and nDBP［(74.1±6.4)mmHg vs.(79.4±7.8)mmHg］after treatment in the observation group were significantly lower than those in the control group(t＝2.535，P＜0.05；t＝2.896，P＜0.05；t＝2.010，P＜0.05；t＝3.303， P＜0.01；t＝2.012，P＜0.05；t＝3.714，P＜0.001).The serum S100B［(60.6±13.4)pg/mL vs.(88.4±15.7)pg/mL］and CT?1［(47.8± 12.5)ng/L vs.(56.7±11.2)ng/L］after treatment in the observation group were significantly lower than those in the control group(t＝7.468，3.751，all P＜0.001).Conclusions Sertraline can effectively improve the anxiety and depression of patients with essentialhypertension complicated with anxiety and depression，assist in lowering blood pressure，and decrease the level of serum S100B and CT?1. |
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