| 刘昊楠,李爱民.动脉瘤性蛛网膜下腔出血后迟发性脑缺血发生机制的研究进展[J].安徽医药,2020,24(12):2333-2336. |
| 动脉瘤性蛛网膜下腔出血后迟发性脑缺血发生机制的研究进展 |
| Research progress on the mechanism of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage |
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| DOI：10.3969/j.issn.1009?6469.2020.12.001 |
| 中文关键词: 蛛网膜下腔出血 颅内动脉瘤 缺氧缺血，脑 血管痉挛，颅内 血小板活化 白细胞介素类 机制 |
| 英文关键词: Subarachnoid hemorrhage Intracranial aneurysm Hypoxia?ischemia,brain Vasospasm,intracranial Platelet activation Interleukins Mechanism |
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| 中文摘要: |
| 迟发性脑缺血是动脉瘤性蛛网膜下腔出血后的一种并发症，是致使不良预后的重要原因。以往认为迟发性脑缺血主要由脑血管痉挛引起，然而近年来对临床和动物模型的研究支持了迟发性脑缺血发生机制的多因素学说。为更好地防治迟发性脑缺血，本课题组综述了如今正在研究的主要发生机制，包括脑血管痉挛、微循环障碍、微血栓形成、皮质扩散性抑制和炎性反应。 |
| 英文摘要: |
| Delayed cerebral ischemia(DCI)is a complication of aneurysmal subarachnoid hemorrhage and an important cause of poor prognosis. In the past，it was believed that DCI was mainly caused by cerebral vasospasm. Recent studies on clinical and ani?mal models have supported the multi?factor theory of the mechanism of DCI. In order to better prevent and treat delayed cerebralischemia，this article reviews some of the major mechanisms under investigation including cerebral vasospasm，microcirculatory dys? function，microthrombosis，cortical spreading depolarizations and neuroinflammation. |
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