| 胡敏.宫颈病变 382例高危人乳头瘤病毒亚型分布及其与宫颈癌的相关性分析[J].安徽医药,2020,24(12):2439-2442. |
| 宫颈病变 382例高危人乳头瘤病毒亚型分布及其与宫颈癌的相关性分析 |
| Distribution of high?risk HPV subtypes in 382 cases of cervical lesions and its correlation with cervical cancer |
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| DOI：10.3969/j.issn.1009?6469.2020.12.027 |
| 中文关键词: 宫颈肿瘤 人乳头瘤病毒 16 人乳头瘤病毒 18 人乳头瘤病毒 52 人乳头瘤病毒 59 亚型分布 相关性 |
| 英文关键词: Uterine cervical neoplasms Human papillomavirus 16 Human papillomavirus 18 Human papillomavirus 52 Human papillomavirus 59 Subtype distribution Correlation |
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| 中文摘要: |
| 目的探讨宫颈病变妇女高危人乳头瘤病毒(HPV)亚型分布及与宫颈癌的相关性分析。方法选取 2016年 1月至 2018年 8月洪湖市妇幼保健院收治的 382例宫颈病变病人进行研究，其中宫颈癌病人 95例(宫颈癌组)宫颈癌前病变病人 135例(癌前病变组)宫颈炎病人 152例(宫颈炎组)对所有受试者进行 HPV检测，比较三组病人 HPV阳性，率、高危 HPV亚型分布、感染类型及高危，HPV亚型分布与宫颈癌临床分，型关系。结果宫颈癌组、癌前病变组 HPV阳性检出率(94.74%、72.59%)高于宫颈炎组(23.03%)(P＜0.001)宫颈癌组明显高于癌前病变组(P＜0.001)；宫颈癌组中 HPV16、HPV18、HPV52、HPV59、总 HPV亚型阳性检出率(32.63%、13.6，8%、10.53%、7.37%、80.00%)高于宫颈炎组(6.58%、4.61%、2.63%、0.67%、17.76%)(P＜0.001)宫颈癌组总 HPV亚型阳性检出率(80.00%)高于癌前病变组(64.44%)(P＜0.001)三组间 HPV16、HPV18、HPV52、 HPV59HPV亚型阳性检出率比较差异有统计学意义(P＜0.05)；宫颈癌组、癌前病变组HPV阳性病人单一型感染率分、总，高危，别为 94.74%、72.41%，明显高于宫颈炎组(P＜0.001)；宫颈癌病人 HPV16亚型在鳞癌中阳性检出率最高，不同临床分型比较差异有统计学意义(P＜0.05)HPV18亚型在腺癌中阳性检出率最高，不同临床分型比较差异有统计学意义(P＜0.05)。结论 HPV亚型分布与宫颈癌发生密，切相关，宫颈病变病人以单一亚型感染为主，其中 HPV16、HPV18与宫颈癌临床分型相关。 |
| 英文摘要: |
| Objective To investigate the distribution of high?risk human papillomavirus(HPV)subtypes in women with cervical le? sions and its correlation with cervical cancer.Methods Three hundred and eighty?two patients with cervical lesions admitted toHonghu Maternal and Child Health Hospital from January 2016 to August 2018 were selected for the study，among them，95 pa? tients with cervical cancer(cervical cancer group)，135 patients with cervical precancerous lesions(precancerous lesion group)， and 152 patients with cervicitis(cervicitis group)，all subjects were tested for HPV，the HPV positive rate，distribution of high?risk HPV subtypes，and types of infection were compared among the three groups，and the relationship between the distribution of high? risk HPV subtypes with clinical stage of cervical cancer were compared.Results The positive rate of HPV in cervical cancer group and precancerous lesion group(94.74%，72.59%)was higher than that in cervicitis group(23.03%)(P＜0.001)，and the positive rate of HPV in cervical cancer group was significantly higher than that in precancerous lesion group(P＜0.001)； the posi? tive rate of HPV16，HPV18，HPV52，HPV59 and total HPV subtypes in cervical cancer group(32.63%，13.68%，10.53%，7.37%，80.00%)was higher than that in cervicitis group(6.58%，4.61%，2.63%，0.67%，17.76%)(P＜0.001)，the positive detection rate of total HPV subtype in cervical cancer group(80.00%)was higher than that in precancerous lesion group(64.44%)(P＜0.001)， the positive detection rates of HPV16，HPV18，HPV52，HPV59 and total HPV subtypes among the three groups were statistically significant(P＜0.05)； the single infection rate of high?risk HPV positive patients in cervical cancer group and precancerous lesiongroup was 94.74% and 72.41%，respectively，which was significantly higher than that in cervicitis group(P＜0.001)，there was sig? nificant difference among the three groups(P＜0.001)； the positive detection rate of HPV16 subtype in patients with cervical can? cer was the highest in squamous cell carcinoma，and the difference between different clinical classifications was statistically signifi? cant(P＜0.05).The positive detection rate of HPV18 subtype in adenocarcinoma was the highest，and the difference between differ? ent clinical classifications was statistically significant(P＜0.05).Conclusion The distribution of HPV subtypes is closely related to the occurrence of cervical cancer，and the patients with cervical lesions are mainly single subtype infection，among which HPV16，HPV18 is related to the clinical classification of cervical cancer. |
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