| 张立营,陈朴,彭宇生,等.传染性单核细胞增多症 128例实验室指标的早期诊断价值[J].安徽医药,2020,24(12):2502-2504. |
| 传染性单核细胞增多症 128例实验室指标的早期诊断价值 |
| The value of laboratory indicators in the early diagnosis of 128 cases of infectious mononucleosis |
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| DOI：10.3969/j.issn.1009?6469.2020.12.042 |
| 中文关键词: 传染性单核细胞增多症 疱疹病毒 4型，人 荧光免疫测定 异型淋巴细胞 衣壳抗原 IgM抗体 EB病毒 ? DNA 诊断 |
| 英文关键词: Infectious mononucleosis Herpesvirus 4,human Fluoroimmunoassay Atypical lymphocytes VCA? IgM EBV?DNA Diagnostic |
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| 中文摘要: |
| 目的探讨异型淋巴细胞、 EB病毒 ?DNA(EBV?DNA)和 EBV抗 CA?IgM(VCA?IgM)阳性率对传染性单核细胞增多症(IM)的诊断价值。方法收集 2018年 9月至 2019年 4月在宜宾市第一人民医院就诊的 128例 IM病儿和 80例健康对照者。测试异型淋巴细胞、 VCA?IgM和 EBV?DNA的阳性率，并比较这 3个指标在 IM诊断中的价值。结果 EB感染组异型淋巴细胞、 VCA?IgM和 EBV?DNA阳性率(61.72%、70.31%、95.31%)明显高于健康对照组，差异有统计学意义(P＜0.001)； EBV?DNA诊断 IM的灵敏度(95.31%)和阴性预测值(92.94%)高于异型淋巴细胞(61.72%、62.02%)和 VCA?IgM(70.31%、66.96%)差异有统计学意义(P＜0.05)而后二者差异无统计学意义(P＞0.05)；三者诊断 IM的特异度和阳性预测值差异无统计学意义，(P＞0.05)。三者联合检测诊，断 IM的灵敏度为 96.88%，特异度为 96.25%。结论 EBV?DNA阳性率对 IM的诊断效能高于其他两项检测指标，但异型淋巴细胞(大于 10%)诊断 IM的特异度达到 100%。若三者联合检测，其对于 IM的早期诊断价值将进一步提升。 |
| 英文摘要: |
| Objective To investigate the diagnostic values of atypical lymphocytes，Epstein?Barr Virus DNA(EBV?DNA)and Ep? stein?Barr Virus Viral Capsid Antigen Antibody(VCA?IgM)positive rates in children with infectious mononucleosis(IM).Meth? ods The 128 patients with IM and 80 healthy controls were enrolled in The First People’s Hospital of Yibin from September 2018 to April 2019.The positive rates of atypical lymphocytes，VCA?IgM and EBV?DNA were tested，and the diagnostic values of these three indicators in IM were compared.Results The positive rates of atypical lymphocytes，VCA?IgM and EBV?DNA in EB?in? fected group(61.72%，70.31%，95.31%)were significantly higher than those in healthy control group，and the difference was statis? tically significant(P＜0.001).The sensitivity and negative predictive value of EBV?DNA in the diagnosis of IM(95.31%，92.94%) were significantly higher than those of atypical lymphocytes(61.72%，62.02%)and VCA?IgM(70.31%，66.96%)，and the difference was statistically significant(P＜0.05).There was no significant difference between the latter two groups(P＞0.05).There were no significant differences in the specificity and positive predictive value of IM between the three(P＞0.05).The sensitivity of the com? bined detection of the three indicators to diagnose IM was 96.88%，and the specificity wa 96.25%.Conclusions The diagnostic ef? ficacy of EBV?DNA positive rate for IM is significantly higher than that of the other two indicators，but the specificity of atypical lymphocytes for the diagnosis of IM(greater than 10%)is 100%.If the three indicators are combined，their value in the early diag? nosis of IM will be further improved. |
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