| 刘洪霞,唐荔,尚观胜.外泌体微小RNA作为肺癌标志物的研究进展[J].安徽医药,2022,26(3):425-428. |
| 外泌体微小RNA作为肺癌标志物的研究进展 |
| Research progress on exosomal microRNAs as markers of lung cancer |
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| DOI：10.396/j.issn.1009-6469.2022.03.001 |
| 中文关键词: 肺肿瘤 外泌体 微小RNA 标志物 诊断 总生存期 |
| 英文关键词: Lung neoplasms Exosomes MicroRNAs Marker Diagnosis Overall survival |
| 基金项目:四川省教育厅重点项目( 17ZA0136) |
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| 中文摘要: |
| 肺癌是当今致死率较高的癌症之一,其早期诊断对于提高治疗效果至关重要。外泌体是肿瘤细胞信号传导过程中的一种重要方式,其内容物包括蛋白质、脂类物质、mRNAs、微小RNA(microRNAs)等。肿瘤细胞和微环境中其他细胞均可以向细胞外基质中释放外泌体,进而参与调控肿瘤的发生和发展。外泌体可体现其来源细胞的部分重要生物学特点,在多种疾病中具有良好的诊断应用前景,以液体诊断领域为甚。该研究从外泌体的生成和作用入手，对外泌体microRNAs在肺癌诊断标志物中的最新研究进展进行综述。 |
| 英文摘要: |
| Lung cancer is one of the most lethal cancers today, and its early diagnosis is essential to improve treatment outcomes.Exosomes are an important method of signal transduction in tumor cells, and their contents include proteins, lipids, mRNAs, microR-NAs, etc. Tumor cells and other cells in the microenvironment can release exosomes into the extracellular matrix and then participate in the regulation of tumor occurrence and development. Exosomes can reflect some of the important biological characteristics of the cells from which they are derived and have good diagnostic application prospects in various diseases, especially in the field of liquid di-agnosis. This article starts with the generation and function of exosomes and reviews the latest research progress on exosomal microR-NAs in the diagnosis of lung cancer. |
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