| 王建霞.经皮冠脉介入术前后血清多配体蛋白聚糖 -4、心型脂肪酸结合蛋白、基质金属蛋白酶 -9变化与心功能的关系[J].安徽医药,2022,26(3):500-504. |
| 经皮冠脉介入术前后血清多配体蛋白聚糖 -4、心型脂肪酸结合蛋白、基质金属蛋白酶 -9变化与心功能的关系 |
| Relationship between serum syndecan-4, heart-type fatty acid binding protein, matrix metalloproteinase-9 and cardiac function before and after percutaneous coronary intervention |
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| DOI：10.3969/j.issn.1009-6469.2022.03.018 |
| 中文关键词: 心肌梗死 心脏功能试验 经皮冠脉介入术 多配体蛋白聚糖 -4 心型脂肪酸结合蛋白 基质金属蛋白酶 -9 |
| 英文关键词: Myocardial infarction Heart function tests Percutaneous coronary intervention Syndecan-4 Heart-type fatty acid binding protein Matrix metal proteinase-9 |
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| 中文摘要: |
| 目的探讨急性心肌梗死( AMI)病人经皮冠脉介入术( PCI)前后的血清多配体蛋白聚糖 -4(Syndecan-4)、心型脂肪酸结合蛋白( H-FABP)、基质金属蛋白酶 -9(MMP-9)的变化及与心功能的关系。方法选取 2017年 2月至 2019年 12月在潢川县人民医院实施 PCI手术治疗的 80例 AMI病人( AMI组)以及同期 40例健康体检者(对照组)作为研究对象，检测所有研究对象的血清 Syndecan-4、H-FABP、MMP-9水平，左室射血分数(LVEF)、左室舒张末期内径( LVEDd)、左室收缩末期内径(LVEDs)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)。结果 PCI治疗前， AMI组病人血清 Syndecan-4(1 644.21±202.82)ng/ L、H-FABP(29.42±7.41)ng/L、MMP-9(39.61±8.02)μmol/L均显著高于对照组［Syndecan-4(941.70±144.02)ng/L、H-FABP(83.61± |
| 英文摘要: |
| Objective To investigate the relationship between serum syndecan-4, heart-type fatty acid binding protein (H-FABP), matrix metalloproteinase-9 (MMP-9) and cardiac function in patients with acute myocardial infarction before and after percutaneous coronary intervention.Methods A total of 80 cases of AMI patients (AMI group) who underwent PCI surgery in Huangchuan County People′s Hospital from February 2017 to December 2019 and 40 cases of healthy subjects (control group) during the same period were selected as study objects, and the serum syndecan-4, H-FABP, MMP-9 levels, Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVEDs), left ventricular end-diastolic volume (LVEDV), and left ventricular end-systolic volume (LVESV) of all study subjects were detected.Results Before PCI treatment, serum syndecan-4 (1 644.21±202.82) ng/L, H-FABP (29.42±7.41) ng/L and MMP-9 (39.61±8.02) μmol/L in the AMI group were significantly higher than those in the control group [syndecan-4 (941.70±144.02) ng/L, H-FABP (83.61±20.53) ng/L, MMP-9 (18.49±4.68) μmol/L] (P<0.001). Before PCI, LVEF (54.08±5.72) in the AMI group was significantly lower than that in the control group (64.01±3.80) (P<0.001), whileLVEDd (47.61±3.22) mm, LVEDs (31.52±3.21) mm, LVEDV (97.61±24.33) mL, LVESV (46.47±15.21) mL) were significantly higherthan those in the control group [LVEDd (44.13±2.60) mm, LVEDs (26.03±2.93) mm, LVEDV (80.18±16.03) mL, LVESV (31.41±13.02) mL] (P<0.001).Before, 3 days and 3 months after PCI treatment, serum syndecan-4 of patients in the AMI group [before treatment (1 650.82±202.60) ng/L, 3 days after treatment (1 303.98±188.62) ng/L, 3 months after treatment (1 088.25±193.32) ng/L], H-FABP[before treatment (83.12±20.53) ng/L, 3 days after treatment (57.53±16.33) ng/L, 3 months after treatment (38.17±19.48) ng/L],MMP-9[before treatment (39.67±12.12) μmol/L, 3 days after treatment (30.16±10.48) μmol/L, 3 months after treatment (24.10±11.03)μmol/L] showed statistically significant differences among different time points(P<0.001). The above indicators showed a decreasingtrend in the course of PCI treatment, and there was statistically significant differences between each time point (P<0.001). Before PCI,the 3 indexes in serum were negatively correlated with LVEF, and positively correlated with other 4 indexes, most of which had statistical significance (P<0.05).Conclusion The serum levels of syndecan-4, H-FABP and MMP-9 in AMI patients are significantly higher than those in healthy subjects, and syndecan-4 and H-FABP are closely related to the impaired cardiac function of patients, but these three indexes gradually decrease after PCI treatment. |
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