| 王洪伟,张建伟,吴云飞.单光子发射计算机断层扫描仪核素骨显像联合血清 Ⅰ型胶原羧基端肽、抗酒石酸酸性磷酸酶 5b诊断乳腺癌骨转移 194例分析[J].安徽医药,2022,26(3):578-581. |
| 单光子发射计算机断层扫描仪核素骨显像联合血清 Ⅰ型胶原羧基端肽、抗酒石酸酸性磷酸酶 5b诊断乳腺癌骨转移 194例分析 |
| Analysis of 194 cases of breast cancer bone metastasis by SPECT radionuclide bone imaging combined with serum I-CTP and TRACP5b |
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| DOI：10.3969/j.issn.1009-6469.2022.03.037 |
| 中文关键词: 乳腺肿瘤 骨转移 单光子发射计算机断层扫描仪核素骨显像 Ⅰ型胶原羧基端肽 抗酒石酸酸性磷酸酶 5b |
| 英文关键词: Breast neoplasms Bone metastasis Single photon emission computed tomography radionuclide bone imaging Type I collagen carboxy terminal telopeptide Tartrate-resistant acid phosphatase 5b |
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| 中文摘要: |
| 目的分析单光子发射计算机断层扫描仪( SPECT)核素骨显像联合血清 Ⅰ型胶原羧基端肽( ⅠCTP)、抗酒石酸酸性磷酸酶 5b(TRACP5b)诊断乳腺癌骨转移的临床价值。方法选取 2016年 1月至 2019年 1月驻马店市中心医院确诊的乳腺癌病人 194例，采用 SPECT对入组病人进行全身显像检查，按 Soloway骨显像分级标准分为 S0组( n=51)、 S1组( n=56)、 S2组( n=63)和 S3组( n=24)同时采用酶联免疫吸附测定( ELISA)检测血清 ⅠCTP、TRACP5b水平，分析 SPECT核素骨显像检测、血清 Ⅰ CTP、TRACP5b检，测以及 SPECT核素骨显像联合血清 ⅠCTP、TRACP5b检测在乳腺癌骨转移诊断中的曲线下面积( AUC)、灵敏度和特异度。结果 SPECT核素骨显像检查显示 194例乳腺癌术后病人中有 143例发生骨转移，转移率为 73.71%，共发现骨转移病灶 1 217个； S0组、 S1组、 S2组和 S3组四组病人血清 ⅠCTP［(4.78±3.61)μg/L，(9.86±3.15)μg/L，(17.02±6.35)μg/L，(21.67± |
| 英文摘要: |
| Objective To analyze the clinical value of single photon emission computed tomography (SPECT) radionuclide bone imaging combined with serum type I collagen carboxyterminal telopeptide (I-CTP) and blood tartrate-resistant acid phosphatase 5b (TRACP5b) in the diagnosis of breast cancer bone metastasis.Methods A total of 194 breast cancer patients diagnosed in ZhumadianCentral Hospital from January 2016 to January 2019 were selected. SPECT was used to perform whole body imaging examination on theenrolled patients, and they were divided into the S0 group (n=51), S1 group (n=56), S2 group (n=63) and S3 group (n=24) according to the Soloway bone imaging grading standard. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum I-CTP and TRACP5b. To analyze the area under the curve (AUC), sensitivity and specificity of SPECT radionuclide bone imaging detection,serum I-CTP, TRACP5b detection and SPECT radionuclide bone imaging combined with serum I-CTP and TRACP5b in the diagnosis of breast cancer bone metastasis.Results SPECT radionuclide bone imaging showed that 143 of 194 breast cancer patients had bonemetastases, the metastasis rate was 73.71%, and there were 1,217 bone metastases. Comparison of serum I-CTP [(4.78±3.61) μg/L,(9.86±3.15) μg/L, (17.02±6.35) μg/L, (21.67±7.25) μg/L] and TRACP5b [(3.59±4.11) U/L, (7.42±2.89) U/L, (10.23±4.68) U/L, (17.81±7.20) U/L] levels in the S0 group, S1 group, S2 group and S3 group showed that the S0 group |
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