| 梁伟智,宋跃飞,李国辉,等.外周血嗜酸性粒细胞与慢性阻塞性肺疾病急性发作风险的关系[J].安徽医药,2022,26(4):738-742. |
| 外周血嗜酸性粒细胞与慢性阻塞性肺疾病急性发作风险的关系 |
| Relationship between blood eosinophils and risk of acute exacerbation of COPD |
| |
| DOI：10.3969/j.issn.1009-6469.2022.04.022 |
| 中文关键词: 肺疾病，慢性阻塞性 嗜酸细胞 最大呼气流量 -容积曲线 预后 |
| 英文关键词: Pulmonary disease, chronic obstructive Eosinophils Maximal expiratory flow-volume curves Prognosis |
| 基金项目: |
|
| 摘要点击次数: 1111 |
| 全文下载次数: 392 |
| 中文摘要: |
| 目的探讨外周循环血嗜酸性粒细胞与慢性阻塞性肺疾病( chronic obstructive pulmonary disease，COPD)病人未来急性加重风险的关系。方法纳入 2015年 1月至 2019年 1月在广州市花都区人民医院各科就诊的 COPD病人共 499例，收集病人临床数据，进行回顾性分析。病人分为对照组和急性发作组，急性发作组进一步根据病人出院后 1年内，有无急性加重发作事件发生分为频发组与非频发组，收集病人年龄、性别、体质量指数( BMI)、是否使用吸入用激素治疗( inhaled corticosteroids， ICS)、静脉血嗜酸性粒细胞计数以及比例、肺功能结果中的第一秒用力呼气容积占预计值比值(FEV1%预计值)(频发组及非频发组均需收集病人急性事件出院后首次出现急性加重时的外周静脉血嗜酸性粒细胞计数及比例)。结果在 499例病人中，急性加重病人有 307例( 61.52%)，在这 307例病人中，有 186例( 60.59%)病人在急性事件出院后 1年内出现 ≥1次的急性加重。急性加重组与对照组、频发组与非频发组在嗜酸性粒细胞计数、嗜酸性粒细胞计数 ≥200个/微升、嗜酸性粒细胞计数 ≥300个/微升、嗜酸性粒细胞比例、嗜酸性粒细胞比例 ≥2%、嗜酸性粒细胞比例 ≥4%、是否使用 ICS治疗均差异无统计学意义(均 P>0.05)；频发组与非频发组病人出院后出现首次急性加重时，其嗜酸性粒细胞计数、嗜酸性粒细胞计数 ≥200个/微升、嗜酸性粒细胞计数≥300个/微升、嗜酸性粒细胞比例、嗜酸性粒细胞比例 ≥2%、嗜酸性粒细胞比例 ≥4%也均差异无统计学意义(均 P>0.05)；但对照组与急性加重组、频发组与非频发组 FEV1%预计值［分别为 67.25(62.90，72.70)比 48.10(32.30，60.50)、 35.60(28.42，48.10)比 62.3(54.70，69.15)］结果差异有统计学意义(均 P<0.05)。结论外周血嗜酸性粒细胞不能预测慢性阻塞性肺疾病病人在未来的急性发作风险，而病人基础肺功能情况与病人未来急性加重风险相关。 |
| 英文摘要: |
| Objective To investigate the relationship between eosinophils in peripheral blood and the risk of acute exacerbation inpatients with chronic obstructive pulmonary disease (COPD).Method A total of 499 patients with Chronic Obstructive Pulmonary Dis ease (COPD) who were treated in Huadu District People's Hospital from January 2015 to January 2019 were selected. The clinical dataof the patients were collected and analyzed retrospectively. Patients were assigned into control group and acute exacerbation group. Ac cording to the occurrence of acute exacerbation events within one year after patient discharge, the acute exacerbation group was furtherdivided into frequent roup and non-frequent group. The age, gender, body mass index (BMI) and inhaling corticosteroids therapy (ICS),peripheral blood eosinophil count and proportion, forced expiratory volume in the first second of pulmonary function results (FEV1 topredicted FEV1 Ratio) were collected (both frequent and non-frequent group were needed to collect the absolute count and proportionof peripheral blood eosinophils in the first acute exacerbation after discharge from hospital).Results Among the 499 patients, 307(61.52%) had acute exacerbation. Among these 307 patients, 186 (60.59%) had acute exacerbation more than once in one year after theoccurrence of acute exacerbation. In control group and acute exacerbation group, in the frequent group and non-frequent group, the eo sinophil count, eosinophil count ≥ 200/μL, eosinophil count ≥ 300/μL, eosinophil proportion, proportion of eosinophils ≥ 2%, propor tion of eosinophils ≥ 4% and ICS treatment show no significant difference (all P>0.05). When the first acute exacerbation occurs in pa tients in the frequent group and the non-frequent group after discharge from hospital, the eosinophil count, eosinophil count≥200/μL,eosinophil count≥300/μL, proportion of eosinophil, proportion of eosinophils ≥2% , proportion of eosinophils≥4% all showed no signifi cant difference. (all P>0.05). However, there was significant difference in the forced expiratory volume in the first second to its predict ed values ratio between the control group and the acute exacerbation group, the frequent group and the non-frequent group [67.25Eosinophilsin peripheral blood can not predict the risk of future acute exacerbation in patients with COPD, and the basic pulmonary function of pa tients is related to the risk of future acute exacerbation. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
