| 何雷,沈冬明.乳腺癌病人绝经前后血清 25羟维生素 D及骨钙素水平与乳腺密度相关性研究[J].安徽医药,2022,26(4):742-746. |
| 乳腺癌病人绝经前后血清 25羟维生素 D及骨钙素水平与乳腺密度相关性研究 |
| Correlation between serum 25-OH vitamin D and osteocalcin and breast density in patients with breast cancer before and after menopause |
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| DOI：10.3969/j.issn.1009-6469.2022.04.023 |
| 中文关键词: 乳腺肿瘤 乳房 X线摄影术 25羟维生素 D 骨钙素 乳腺密度 绝经前期 绝经后期 |
| 英文关键词: Breast neoplasms Mammography 25 hydroxyvitamin D Osteocalcin Breast density Premenopause Postmenopause |
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| 中文摘要: |
| 目的通过评估乳腺癌病人乳腺密度与 25羟维生素 D(25 hydroxyvitamin D，25-OH-VD)和骨钙素浓度之间的关系，为乳腺癌病人风险性评估提供科学依据。方法采用病例对照方法，纳入 2017年 6月至 2018年 12月在上海市宝山区罗店医院确诊乳腺癌病人 108例，其中绝经前病人 53例，绝经后病人 55例，按 Wolfe方法分为低风险和高风险组，以高风险组乳腺癌病人为病例组，低风险组病人为对照组，收集病人基本信息、血清 25-OH-VD及骨钙素等资料，分析绝经前后不同风险组乳腺癌病人血清学指标间相关性。结果绝经前、后病人的 25-OH-VD和骨钙素分别是(49.41±3.84)nmol/L，(29.04±4.18)nmol/L和(4.27±1.65)μg/L， |
| 英文摘要: |
| Objective To provide a scientific basis for risk assessment of breast cancer patients by evaluating the relationship be tween breast density and 25-hydroxyvitamin D (25-OH-VD) and osteocalc in concentrations in breast cancer patients.Methods Usingthe case control method, 108 cases of breast cancer were diagnosed in Luodian Hospital of Baoshan District from June 2017 to December2018, including 53 cases of premenopausal patients and 55 cases of postmenopausal patients. They were assigned into low-risk and high-risk groups according to the Wolfe method, with high-risk breast cancer patients as the case group and low-risk group as the controlgroup. The basic information about patients, serum 25 hydroxy vitamin D and osteocalcin and other data were collected to analyze thecorrelation between serological indicators of breast cancer patients in different risk groups before and after menopause.Results 25 hy droxy vitamin D and osteocalcin in premenopausal and post-menopausal patients were (49.41±3.84) nmol/L, (29.04±4.18) nmol/L and(4.27±1.65) μg/L, (14.35±2.42) ng/ml, respectively. There were statistically significant between 25-hydroxyvitamin D and osteocalcin (both P<0.001). Among postmenopausal patients, 25-hydroxyvitamin D and osteocalcin in the low-risk group and the high-risk groupwere (40.15±4.64) nmol/L, (25.92±3.72) nmol/L and (10.52±2.51) ng/ml, (17.67±2.48) ng/ml, respectively. There were statistically sig nificant between the low-risk group and the high-risk group for 25-hydroxyvitamin D and osteocalcin (both P<0.001). Logistical regres sion analysis showed that mammograms in patients with high-risk patterns were associated with 25-hydroxyvitamin D (β= 0.547, P= 0.004) and osteocalcin levels (β=0.180, P=0.002), and correlation analysis showed the correlation between 25-hydroxyvitamin D and os teocalcin in premenopausal (r= 0.280) and postmenopausal (r= 0.557) was statistically significant (both P<0.05).Conclusion 25-hy droxyvitamin D and osteocalcin are associated with the risk of postmenopausal breast cancer and can be used as a reference for breastcancer risk assessment. |
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