| 黄勇杰,曾思红,黄彩燕,等.卵巢交界性子宫内膜样肿瘤 4例临床病理观察[J].安徽医药,2022,26(4):801-804. |
| 卵巢交界性子宫内膜样肿瘤 4例临床病理观察 |
| Clinicopathological observation of 4 cases of ovarian borderline endometrioid tumor |
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| DOI：10.3969/j.issn.1009-6469.2022.04.036 |
| 中文关键词: 卵巢肿瘤 角蛋白 9 抗原，肿瘤相关，碳水化合物 受体，雌激素 肿瘤蛋白质类 交界性子宫内膜样肿瘤 预后 |
| 英文关键词: Ovarian neoplasms Keratin-9 Antigens,tumor-associated, carbohydrate Receptors,estrogen Neoplasm pro teins Endometrioid borderline tumor Prognosis |
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| 中文摘要: |
| 目的深入了解卵巢交界性子宫内膜样肿瘤( EBT)的临床病理特点、鉴别诊断、治疗和预后。方法对清远市人民医院病理科 2012年 1月至 2019年 9月诊断的 4例卵巢 EBT的临床资料、组织学形态、免疫组化特点及预后进行分析总结，并复习相关文献。结果 4例因不规则阴道出血、下腹胀痛或发现盆腔占位入院，均行子宫及双附件切除术，其中 3例行盆腔淋巴结清扫。镜下见排列紊乱、拥挤的子宫内膜样腺体，上皮细胞具有轻度或中度不典型性，部分区域上皮呈复层，腺体间见丰富的纤维间质； 1例伴有子宫内膜样囊肿，腺体伴桑葚样鳞状化生； 1例见上皮内癌及间质微浸润，且对侧卵巢及宫腔均见低级别子宫内膜样癌，术后多次化疗。肿瘤细胞角蛋白(CK)角蛋白 7(CK7)糖类抗原(CA125)雌激素受体(ER)及孕激素受体(PR)(＋)波形蛋白(Vimentin)部分(＋)蛋白质 53(P53)、约 5%~10%(＋)、增殖指数(Ki-67)约、5%~25%(＋)，Wilms肿瘤蛋白 1(WT均 |
| 英文摘要: |
| Objective To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of ovarian endo metrioid borderline tumor (EBT).Methods The clinical data, histological morphology, immunohistochemical characteristics and prog nosis of 4 cases of ovarian EBT diagnosed in the Department of Pathology, Qingyuan People's Hospital from January 2012 to September2019 were analyzed and summarized, and the relevant literature was reviewed.Results 4 cases were admitted to hospital because of ir regular vaginal bleeding, abdominal distention or pelvic space occupying. All patients underwent hysterectomy and bilateral adnexecto my, 3 cases of them underwent pelvic lymph node dissection. Microscopically, there were disordered and crowded endometrioid glands.The epithelial cells were mildly or moderately atypical. The epithelium of some areas was stratified, and there was abundant fibrousstroma between the glands. One case was accompanied by endometrioid cyst, and the glands with mulberry-like squamous metaplasia;one case was seen with intraepithelial carcinoma and interstitial microinvasion, and the other side of ovary and uterine cavity were seenwith low-grade endometrial carcinoma, and after operation, multiple chemotherapy was performed. Tumor cells were positive for Cyto keratin (CK), Cytokeratin 7 (CK7), Carbohydrate antigen 125 (CA125), estrogen receptor (ER) and progesterone receptor (PR), partiallypositive for Vimentin, protein 53 (P53, about 5% ~ 10%), and negative for Wilms tumor 1 (WT-1). Ki-67 index was about 5%~25%. Follow-up up to date (ranging from 7 months to 7.5 years), all the 4 cases were in tumor-free survival state, with no signs of recurrence or metastasis.Conclusion Ovarian endometrioid borderline tumors are rare and can coexist with endometriosis or endomet-rioid carci noma. Surgery is the main treatment and the prognosis is good. |
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