| 杨伟昂,杨兵,马焕丽,等.两种泻药的安全性及对肠道菌群影响的对比研究[J].安徽医药,2022,26(6):1249-1253. |
| 两种泻药的安全性及对肠道菌群影响的对比研究 |
| A comparative study on the safety and the effects on intestinal microbiota by two cathartic drugs |
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| DOI：10.3969/j.issn.1009-6469.2022.06.045 |
| 中文关键词: 泻药 术前用药法 结肠镜检查 复方聚乙二醇电解质散 甘露醇 肠道准备 不良反应 肠道菌群 对比研究 |
| 英文关键词: Cathartics Premedication Colonoscopy Polyethylene glycol electrolyte powder Mannitol Intestinal cleansing Adverse reactions Intestinal microbiota Comparative study |
| 基金项目:深圳市龙岗区 2018年度医疗卫生科技计划项目( LGKCYLWS2018000022) |
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| 中文摘要: |
| 目的明确两种导泻药物对肠道菌群的影响以及是否会导致迟发性药物不良反应，探讨其相关性。方法将 2018年 10月至 2019年 6月深圳市龙岗中心医院收治的 61例拟行结肠镜检查的病人按随机数字表法、双盲分成两组， A组 31例、 B组 30例分别采用复方聚乙二醇电解质散、 20%甘露醇清洁肠道，于导泻前、导泻后 d1、d14取粪便送检，标本直接涂片法检测细菌总数、革兰阳性菌数量，稀释性平板菌落计数法 +快速细菌鉴定法检测肠球菌、大肠杆菌数量；导泻后 d14电话随访病人是否出现迟发性药物不良反应。结果导泻后 d1，两组细菌总数［ A组:(127.5±30.6)个/油镜比( 3 409.7±734.6)个 /油镜， B组:(110.9± |
| 英文摘要: |
| Objective To observe the effects of two cathartic drugs on intestinal microbiota and the likelihood of delayed adversedrug reactions, followed by exploring their correlations.Methods Sixty-one patients, admitted for colonoscopy examination in Long‐gang Central Hospital in Shenzhen from October 2018 to June 2019, were assigned into group A (n=31) and group B (n=30) by random number table and double-blind methods. Group A and group B were prepared for intestinal cleansing with polyethylene glycol electrolyte powder and 20% mannitol, respectively. Appropriate amounts of fresh feces were taken for examination before bowel cleansing(base line), 1 d and 14 d after the catharsis usages. The counts of total bacteria and Gram-positive bacilli in feces were detected by thedirect smear method. Enterococcus and Bacillus Coli counts were determined by diluted plate colony count plus rapid bacteria identification. The patients were given the follow-up visits by telephone in the 14 days after catharsis, in order to identify delayed adverse drug reactions.Results In the 1 d after catharsis, the counts of total bacteria [group A: (127.5±30.6) vs. (3 409.7±734.6); group B: (110.9± 27.8) vs. (3 300.0±755.7)] and Gram-positive bacilli were significantly decreased compared with those in the base line; the counts of Enterococcus and Bacillus Coli were significantly increased in both groups, while group B had more increment than group A (P<0.05). In the 14 d after the catharsis, the counts of total bacteria [group A: (3 380.7±794.3); group B: (3 250.0±813.1)] and Gram-positive bacilliin both groups were almost recovered to the base line; the counts of Enterococcus and Bacillus Coli remained in increased levels in bothgroups without significant differences between them (P>0.05). In 14 d after catharsis, both groups had delayed adverse drug reactions,which were correlated with the changes in intestinal microbiota (r=0.68, P<0.01); group B had a higher incidence of delayed adverse drug reactions compared with that of group A [30.0% (9/30) vs. 6.45% (2/31); P<0.05].Conclusions The quantity and composition ofintestinal microbiota can be significantly changed by cathartic drugs, leading to delayed adverse drug reactions. Compared with 20%mannitol, polyethylene glycol electrolyte powder for bowel cleansing imposes fewer effects on intestinal microbiota and a lower rate ofdelayed adverse drug reactions, suggesting its greater value for clinical practices. |
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