| 张金桂,王超.抗体药物的药物代谢动力学特点及研究进展[J].安徽医药,2022,26(7):1282-1286. |
| 抗体药物的药物代谢动力学特点及研究进展 |
| Pharmacokinetic characteristics and research advances in antibody drugs |
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| DOI：10.3969/j.issn.1009-6469.2022.07.003 |
| 中文关键词: 免疫球蛋白类 糖基化 抗体药物 药物代谢动力学 纳米抗体 双特异性抗体 抗体药物偶联物 |
| 英文关键词: Immunoglobulins Glycosylation Antibody drugs Pharmacokinetics Nanobodies Bispecific antibodies An-tibody drug conjugates |
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| 中文摘要: |
| 抗体药物是一种可与相应抗原发生特异性结合的免疫球蛋白。该研究从抗体药物的结构入手，对抗体药物的药物代谢动力学基本特点进行综述，并着重介绍了其不同于小分子药物的独特代谢特征，主要包括与靶点介导的药物处置、新生儿 Fc受体介导的循环再利用、糖基化修饰和电荷异质性对清除速率的影响以及与抗药物抗体相结合导致清除加快。最后总结了纳米抗体、双特异性抗体、抗体药物偶联物等新型抗体药物的药物代谢动力学研究进展。 |
| 英文摘要: |
| Antibody drugs are immunoglobulins that can specifically bind to corresponding antigens. In this review, we start with thestructure of antibody drugs and review the basic characteristics of the pharmacokinetics of antibody drugs. We highlight the unique met-abolic characteristics of antibody drugs that differ from small molecule drugs, mainly including target-mediated drug disposition, neona-tal Fc receptor-mediated recycling, glycosylation modifications and the effect of charge heterogeneity on clearance rates, and binding to anti-drug antibodies leading to accelerated clearance. Finally, the research progress on the pharmacokinetics of new antibody drugs,such as nanobodies, bispecific antibodies, and antibody-drug conjugates, is summarized. |
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