| 王晶,李培,白玉芝,等.心肌梗死病人血清半乳糖凝集素 3和生长刺激表达基因 2蛋白与左室重构相关性[J].安徽医药,2022,26(7):1415-1419. |
| 心肌梗死病人血清半乳糖凝集素 3和生长刺激表达基因 2蛋白与左室重构相关性 |
| Correlation of serum galectin-3 and growth-stimulating gene 2 protein with left ventricular remodeling in patients with acute myocardial infarction |
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| DOI：10.3969/j.issn.1009-6469.2022.07.033 |
| 中文关键词: 心肌梗死 半乳糖凝集素 3 生长调节素类 超声心动描记术，多普勒，彩色 基质金属蛋白酶类 每搏输出量 左室重构 |
| 英文关键词: Myocardial infarction Galectin-3 Somatomedins Echocardiography,doppler,color Matrix metalloproteinases Stroke volume Left ventricular remodeling |
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| 中文摘要: |
| 目的探究血清半乳糖凝集素 3(Gal-3)和生长刺激表达基因 2蛋白( sST2)在急性心肌梗死病人中的表达情况以及与左室重构的相关性。方法选择 2019年 1月至 2020年 11月于首都医科大学附属北京朝阳医院收治的 120名急性心肌梗死(AMI)病人，包括 78例 ST段抬高 MI(STEMI)病人和 42例非 ST段抬高 MI(NSTEMI)病人，选择 40例与病人组基线特征相似个体作为对照组。血常规检测白细胞数目和中性粒细胞数目，采用 ELISA检测急性心肌梗死病人血清 Gal-3和 sST2，以及基质金属蛋白酶 2(MMP-2)和基质金属蛋白酶 9(MMP-9)表达水平，超声心动图检查左心室舒张末期容积(LVEDV)左心室收缩末期容积( LVESV)左室舒张末期直径( LVEDD)和左心室射血分数( EF)。结果与对照组比较， AMI病人白细胞数，目和中性粒细胞数目增多，血清，中 Gal-3、sST2、MMP-2和 MMP-9水平均升高，左心室重构指标 LVEDV、LVEDD和 LVESV水平上升，而 EF水平降低，差异有统计学意义( P<0.05)； STEMI组的白细胞数目和中性粒细胞数目、 Gal-3、sST2、MMP-2和 MMP-9水平、 LVEDV、 LVEDD和 LVESV水平高于 NSTEMI组( P<0.05)其中 STEMI组 Gal-3含量为( 15.65±3.12)μg/L，sST2表达水平为( 11.23±2.61) μg/L，LVEDV为( 119.45±20.34)mL，LVEDD为(52，.64±6.98)mm，LVESV为( 43.22±8.12)mL，而 STEMI组 Gal-3含量为( 9.27± |
| 英文摘要: |
| Objective To investigate the expression of serum galectin-3 (Gal-3) and growth stimulating gene 2 protein(sST2) in pa-tients with acute myocardial infarction (AMI) and their correlation with left ventricular remodeling.Methods A total of 120 patients with AMI, including 78 patients with ST-segment elevation MI (STEMI) and 42 patients with non-ST-segment elevation MI (NSTEMI),were selected from January 2019 to November 2020 in the Beijing West Campus of Beijing Chaoyang Hospital, and 40 individuals withbaseline characteristics similar to those of patient group were selected as the control group. The blood counts of leukocytes and neutro-phils were measured routinely, and the serum levels of Gal-3, sST2, matrix metalloproteinase 2 (MMP-2) and MMP-9 in patients with AMI were measured by enzyme-linked immunosorbent assay (ELISA). Left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic diameter (LVEDD), and left ventricular ejection fraction (EF) were exam-ined by echocardiography.Results Compared with the control group, the number of leukocytes and neutrophils in AMI patients in-creased, the levels of Gal-3, sST2, MMP-2 and MMP-9 in serum increased, and the levels of the left ventricular remodeling indexesLVEDV, LVEDD and LVESV increased, while the EF level decreased, and the difference was statistically significant (P < 0.05). The number of leukocytes and neutrophils, Gal-3, sST2, MMP-2 and MMP-9 levels, LVEDV, LVEDD and LVESV in the STEMI group were higher than those in the NSTEMI group (P < 0.05). The content of Gal-3 in the STEMI group was (15.65±3.12)μg/L, the expression lev-el of sST2 was (11.23±2.61)μg/L, the LVEDV was (119.45±20.34)mL, the LVEDD was (52.64±6.98)mm, and the LVESV was (43.22±8.12) mL, while the content of Gal-3 in the NSTEMI group was (9.27±2.63)μg/L, the expression level of sST2 was (8.32±2.11)μg/L, the LVEDV was (107.68±18.66)mL, the LVEDD was(42.95±5.67)mm, and the LVESV was (39.75±8.52)mL. In contrast, the EF in the STE-MI group was (43.85±5.74)%, while the EF in the NSTEMI group was (53.69±6.21)%, and the difference was statistically significant (P <0.05). Pearson correlation coefficient analysis showed that the expression level of Gal-3 in the serum of AMI patients was positivelycorrelated with the levels of the left ventricular remodeling indexes LVEDV, LVEDD and LVESV (r=0.62,0.58,0.59); the expression level of sST2 was positively correlated with LVEDV, LVEDD and LVESV levels (r=0.69,0.65,0.63,P<0.05); and EF levels were nega-tively correlated with serum Gal-3 and sST2 expression levels (r=.0.57,.0.60,P<0.05).Conclusions Elevated serum Gal-3 and sST2 are closely related to left ventricular remodeling in myocardial infarction. |
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