| 李振云,崔俊伟,刘卫国,等.活血化瘀方对血清中 γ-干扰素诱导蛋白 -10、单核细胞趋化蛋白 -1、转化生长因子 -β1水平的影响及结核性胸膜炎疗效的研究[J].安徽医药,2022,26(7):1449-1453. |
| 活血化瘀方对血清中 γ-干扰素诱导蛋白 -10、单核细胞趋化蛋白 -1、转化生长因子 -β1水平的影响及结核性胸膜炎疗效的研究 |
| Effect of Huoxue Huayu recipe on serum levels of γ-interferon-inducible protein-10, monocyte chemoattractant protein-1 and transforming growth factor-β1 and the curative effect of tuberculous pleurisy |
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| DOI：10.3969/j.issn.1009-6469.2022.07.041 |
| 中文关键词: 结核，胸膜 活血化瘀方 γ-干扰素诱导蛋白 -10 单核细胞趋化蛋白 -1(MCP-1) 转化生长因子 -β1 肿瘤坏死因子 α 血府逐瘀汤 |
| 英文关键词: Tuberculosis,pleural Huoxue Huayu recipe γ-interferon-induced protein-10 Monocyte chemoattractant protein-1 (MCP-1) Transforming growth factor-β1 Tumor necrosis factor-α |
| 基金项目:河南省医学科技攻关计划项目( 2018020344) |
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| 中文摘要: |
| 目的观察活血化瘀方治疗结核性胸膜炎对病人胸膜厚度及血清中 γ-干扰素诱导蛋白 -10(IP-10)、单核细胞趋化蛋白-1(MCP-1)、转化生长因子 -β1(TGF-β1)水平的影响。方法收集新乡医学院第一附属医院 2017年 4月至 2019年 12月收治的结核性胸膜炎病人 104例，采用随机数字表法分为常规组及中医组，每组 52例。常规组给予胸腔穿刺抽液术 +抗结核药物治疗，中医组在常规组基础上加用活血化瘀方(血府逐瘀汤加减)治疗。治疗 8周后，比较两组治疗前后血清中细胞因子水平及胸膜厚度的变化，两组胸膜腔穿刺抽液次数、治疗总有效率和治疗期间不良反应情况。结果治疗 8周后，中医组总有效率 |
| 英文摘要: |
| Objective To observe the effect of Huoxue Huayu recipe on pleural thickness and serum levels of γ-interferon-induced pro-tein-10(IP-10),monocytechemoattractantprotein-1(MCP-1)andtransforminggrowthfactor-β1(TGF-β1)inpatientswithtuberculouspleu-risy.Methods Atotalof104patientswithtuberculosispleurisywhowereadmittedtotheFirstAffiliatedHospitalofXinxiangMedicalCol-lege from April 2017 to December 2019 were enrolled anddivided into aroutinegroup and a traditional Chinese medicine groupbythe ran-dom number table method, with 52 cases in each group. The routine group was treated with thoracentesis plus anti-tuberculosis drugs, and thetraditionalChinesemedicinegroupwastreatedwith Huoxue Huayu recipe(Xuefu Zhuyu decoction)onthebasisoftheroutinegroup.Af-ter 8 weeks of treatment, the changes in cytokine levels and pleural thickness, the number of pleural punctures, the total effective rate oftreatment and the adverse reactions during treatment were compared between the two groups before and after treatment.Results After 8 weeks of treatment, the total effective rate in the traditional Chinese medicine group (92.31%) was higher than that in the routine group(76.92%); the number ofpleuralpunctures in the traditional Chinese medicine group wasless than thatin the controlgroup (P < 0.05).Dur-ing the treatment period, there was no significant difference in the adverse reaction rate between the traditional Chinese medicine group (69.2%)andtheroutinegroup(71.2%)(P >0.05).After8weeksoftreatment,theserumlevelsofIP-10,MCP-1,TGF-β1,tumornecrosisfac-tor-α (TNF-α), interleukin-5 (IL-5), and IL-10 decreased compared with before treatment, and pleural thickness increased. Serum levels of IP-10, MCP-1, TGF-β1, TNF-α, IL-5, IL-10 and pleural thickness in the traditional Chinese medicine group [(286.35±46.14)ng/L, (23.71±4.74)μg/L,(159.85±61.85)μg/L, (374.39±46.05)ng/L, (168.63±32.05)ng/L, (84.32±29.54)ng/L, (2.76±0.36) mm] were lower than those intheroutinegroup[(359.62±57.48)ng/L,(29.87±6.45)μg/L,(204.95±76.44)μg/L,(425.85±57.52)ng/L,(209.68±41.41)ng/L,(117.43±45.21)ng/L, (3.15±0.42)mm] (P<0.05).Conclusion Huoxue Huayu recipe in the treatment of tuberculous pleurisy can regulate the expressionlevelsofrelatedcytokinesandreducethedegreeofpleuralthickeningwithoutincreasingadversereactions. |
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