| 鲍治诚,吴亚平,张蕾,等.血脂个体化调控联合地中海饮食模式治疗缺血性脑卒中100 例[J].安徽医药,2022,26(8):1640-1644. |
| 血脂个体化调控联合地中海饮食模式治疗缺血性脑卒中100 例 |
| Effect of individual regulation of blood lipid combined with the mediterranean diet pattern in ischemic stroke:100 cases |
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| DOI：10.3969/j.issn.1009-6469.2022.08.036 |
| 中文关键词: 脑梗死 卒中 血脂 个体化调控 地中海饮食模式 斑块指数 达标率 |
| 英文关键词: Brain infarction Stroke Blood lipids Individualized regulation Mediterranean diet pattern Plaque index Compliance rate |
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| 中文摘要: |
| 目的探讨血脂个体化调控联合地中海饮食模式治疗缺血性脑卒中的临床效果。方法选取2017年7月至2018年6月在昆山市第一人民医院就诊的符合入选标准的缺血性脑卒中病人300例，采用随机数字表法分成A、B、C组，每组100例。A组给予血脂个体化调控联合地中海饮食模式，B组给予血脂个体化调控联合低盐低脂饮食，C组给予强化降脂联合地中海饮食模式，比较三组血脂达标率、达标时间、斑块逆转程度、不良反应、卒中复发率、病人预后［Barthel 指数量表(BI)评分、美国国立卫生院神经功能缺损(NIHSS)评分］。结果干预6周、12周后A组、C组低密度脂蛋白胆固醇(LDL-C)达标率、BI指数评分大于B组，NIHSS评分及斑块指数低于B组(除干预12周C组斑块指数)，均差异有统计学意义(P<0.05)。A组(6.15±2.22)周、C组(7.07±2.57)周血脂达标时间小于B组(10.68±3.08)周，A组血脂达标时间小于C组，均差异有统计学意义(P<0.05)。12个月后A组、C组卒中复发率均低于B组(P<0.05)。A组、B组不良反应发生率(除伴发糖尿病外)均低于C组(P<0.05)。结论缺血性脑卒中病人采用血脂个体化调控联合地中海饮食模式治疗，能提高血脂达标率，缩短达标时间，改善病人预后，降低卒中复发率及不良反应发生率，值得推广应用。 |
| 英文摘要: |
| Objective To investigate the effect of individualized regulation of blood lipids combined with Mediterranean diet pattern in the treatment of ischemic stroke.Methods A total of 300 patients with ischemic stroke who met the inclusion criteria in the First People's Hospital of Kunshan from July 2017 to June 2018 were selected,and patients were randomly divided into group A,B and C,with 100 cases in each group. Group A was given individualized blood lipid regulation combined with a Mediterranean diet pattern,group B was given individualized blood lipid regulation combined with a low-salt and low-fat diet, and group C was given an enhanced lipid-lowering combined Mediterranean diet pattern. Statistical comparisons were made among the three groups in terms of blood lipid compliance rate, time to compliance, degree of plaque reversion, adverse reactions, stroke recurrence rate, and patient prognosis (BI in?dex score, NIHSS score).Results Ldl-c compliance rate and BI index score of group A and group C were higher than those of group B after 6 weeks and 12 weeks of intervention, while NIHSS score and plaque index were lower than those of group B (except for the plaque index of group C after 12 weeks of intervention), with statistically significant differences (P<0.05). The reaching time of blood lipid in group A [(6.15±2.22) week] and group C [(7.07±2.57) week] was shorter than that in group B [(10.68±3.08) week], and the reaching time of blood lipid in group A was shorter than that in group C, with statistically significant differences (P<0.05).After 12 months, the recurrence rate of stroke in group A and group C was lower than that in group B (P<0.05). The incidence of adverse reac?tions in group A and group B (except for diabetes) was lower than that in group C (P<0.05).Conclusion The individualized regulation of blood lipids combined with the Mediterranean diet pattern in patients with ischemic stroke can improve the rate of blood lipid compli?ance and shorten the time to achieve the standard, improve the prognosis of patients, reduce the recurrence rate of stroke and the inci?dence of adverse reactions, which is worthy of popularization and application. |
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