| 吴云,金汉生.原发性非小细胞肺癌肺叶切除术后血清白蛋白、碱性磷酸酶表达与预后相关性[J].安徽医药,2022,26(9):1874-1878. |
| 原发性非小细胞肺癌肺叶切除术后血清白蛋白、碱性磷酸酶表达与预后相关性 |
| Correlations between serum albumin and alkaline phosphatase expressions and prognosis in patients with primary non-small cell lung cancer after lobectomy |
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| DOI：10.3969/j.issn.1009-6469.2022.09.042 |
| 中文关键词: 癌，非小细胞肺 肺切除术 白蛋白 碱性磷酸酶 预后 |
| 英文关键词: Carcinoma, non-small-cell lung Pneumonectomy Albumin Alkaline phosphatase Prognosis |
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| 中文摘要: |
| 目的探究原发性非小细胞肺癌肺叶切除术后血清白蛋白、碱性磷酸酶(ALP)表达水平及其与预后关系。方法回顾性选取2013年9月至2016年9月武汉市汉口医院收治的原发性非小细胞肺癌病人74例作为研究对象(非小细胞肺癌组)，另选取同期在该院体检显示健康者70例作为健康对照组。采用酶联免疫吸附测定检测病人血清白蛋白、ALP表达水平，并分析二者与病人预后关系。结果与健康对照组术前相比，非小细胞肺癌组术前血清白蛋白表达水平明显降低［(59.55±6.73)g/L比(35.67±6.18)g/L］，ALP表达水平明显升高［(34.19±4.07)U/L比(137.95±16.04)U/L］(P<0.05)；与健康对照组术后相比，非小细胞肺癌组术后血清白蛋白表达水平明显降低［(59.55±6.73)g/L比(43.82±6.51)g/L］，ALP表达水平明显升高［(34.19±4.07)U/L比(68.61±6.58)U/L］(P<0.05)。与术前相比，术后非小细胞肺癌组血清白蛋白表达水平明显升高，ALP表达水平明显降低(P<0.05)。与高中分化、TNM分期Ⅰ~Ⅱ期、无淋巴结转移、术后化疗、生存病人比较，低分化、TNM分期Ⅲ期、淋巴结转移、术后未化疗、死亡病人术后血清白蛋白水平明显降低，ALP水平明显升高(P<0.05)。白蛋白高表达组3年总生存率明显高于白蛋白低表达组，ALP高表达组3年总生存率明显低于ALP低表达组(P<0.05)。TNM分期Ⅲ期、淋巴结转移、术后低白蛋白水平、高ALP水平是影响非小细胞肺癌病人不良预后发生的独立危险因素(P<0.05)。结论原发性非小细胞肺癌病人肺叶切除术后血清白蛋白水平明显降低，ALP水平明显升高，与肿瘤进展和病人生存率密切相关，对病人预后有一定评估价值。 |
| 英文摘要: |
| Objective To investigate the expression levels of serum albumin and alkaline phosphatase (ALP) in patients with primary non-small cell lung cancer after lobectomy, and its relationship with prognosis.Methods A total of 74 patients with primary nonsmall cell lung cancer (non-small cell lung cancer group) treated in Wuhan Hankou hospital from September 2013 to September 2016 were retrospectively selected as the study objects. In addition, 70 healthy people who were examined in the hospital in the same period were selected as the healthy control group. The expressions of albumin and ALP in serum were detected by enzyme-linked immunosorbent assay, and the relationships between them and the prognosis of the patients was analyzed.Results Compared with the healthy control group, the preoperative serum albumin expression level in the non-small cell lung cancer group was significantly lower [(59.55±6.73) g/L vs. (35.67±6.18) g/L], and the ALP expression level was significantly higher [(34.19±4.07) U/L vs. (137.95±16.04) U/L] (P<0.05). Compared with the healthy control group, the expression level of serum albumin in the non-small cell lung cancer group decreased significantly [(59.55±6.73) g/L vs. (43.82±6.51) g/L], and the expression level of ALP increased significantly [(34.19±4.07) U/L vs. (68.61±6.58) U/L] (P<0.05). Compared with that before operation, the expression of albumin in the non-small cell lung cancer group after operation was significantly higher, and the expression level of ALP was significantly lower (P<0.05). Compared with the patients with high and middle differentiation, TNM stage Ⅰ-Ⅱ, non lymph node metastasis, postoperative chemotherapy and survival, the serum albumin level of the patients with low differentiation, TNM stage Ⅲ, lymph node metastasis, non chemotherapy after operation and death was significantly lower, and the ALP level was significantly higher (P<0.05). The 3-year overall survival rate of albumin high expression group was significantly higher than that of albumin low expression group, and that of ALP high expression group was significantly lower than that of ALP low expression group (P<0.05). TNM stage Ⅲ, lymph node metastasis, postoperative low albumin level and high ALP level were independent risk factors for poor prognosis of non-small cell lung cancer (P<0.05).Conclusion The serum albumin level of patients with primary non-small cell lung cancer after lobectomy is significantly lower, and the ALP level is significantly higher,which are closely related to tumor progression and survival rate of patients, and have certain evaluation value for prognosis of patients. |
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