| 万茜茜,刘贺婷,王家凤,等.A 型肉毒毒素注射治疗急性共同性内斜视20 例的早期疗效观察[J].安徽医药,2022,26(9):1884-1887. |
| A 型肉毒毒素注射治疗急性共同性内斜视20 例的早期疗效观察 |
| 20 cases of acute concomitant esotropia |
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| DOI：10.3969/j.issn.1009-6469.2022.09.044 |
| 中文关键词: 内斜视 A型肉毒毒素 眼外科手术 动眼肌 有效性 并发症 |
| 英文关键词: Esotropia Botulinum toxin type A Ophthalmologic surgical procedures Oculomotor muscles Efficacy Complications |
| 基金项目:安徽省科技厅重点研究与开发计划项目(201904d07020003) |
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| 中文摘要: |
| 目的评价A型肉毒毒素注射治疗急性共同性内斜视的临床疗效。方法纳入2020年1月至2021年2月就诊于安徽医科大学第二附属医院的35例急性共同性内斜视病人，根据治疗方法的不同分为注射组20例和手术组15例，其中注射组又分为结膜微切口组(注射组a)和无结膜切口组(注射组b)，每组各10例。手术组根据术前三棱镜度数设计手术方案，注射组予以内直肌A型肉毒毒素注射，比较各组间3个月时的有效性和安全性。结果治疗后3个月时注射组与手术组治愈率分别为75.0%和86.7%，两组间比较差异无统计学意义(P>0.05)，注射组a与注射组b治愈率分别为70.0%和80.0%，两组间比较差异无统计学意义(P>0.05)。注射组治疗后出现上睑下垂2例，轻度外斜视1例，均于1个月之内恢复，1例复发，予以重复注射。均未出现结膜淤血、瘢痕、组织粘连等并发症。结论A型肉毒毒素注射治疗急性共同性内斜视效果较好，安全性、可重复性高，可作为急性共同性内斜视早期治疗的首选治疗方案。 |
| 英文摘要: |
| Objective To evaluate the clinical efficacy of botulinum toxin type A injection in the treatment of acute concomitant esotropia.Methods Thirty-five patients with acute concomitant esotropia who visited the Second Affiliated Hospital of Anhui Medical University from January 2020 to February 2021 were included. According to different treatment methods, they were divided into an injection group (n = 20) and an operation group (n = 15). The injection group was further divided into the conjunctival microincision group (injection group A) and the nonconjunctival incision group (injection group B), with 10 cases in each group. In the operation group, the operation plan was designed according to the preoperative prism degree, and the injection group was injected with botulinum toxin type A in the medial rectus muscle. The efficacy and safety of each group at 3 months were compared.Results At 3 months after treatment, the cure rates of injection group and operation group were 75.0% and 86.7%, respectively, and there was no significant difference between the two groups (P > 0.05). The cure rates of the injection group A and the injection group B were 70% and 80%, respectively,and there was no difference between the two groups (P > 0.05). In the injection group, 2 cases of ptosis, 1 case of mild exotropia occurred after treatment; all recovered within 1 month, and 1 case recurred, and the injection was repeated. There were no complications such as conjunctival congestion, scarring or tissue adhesion.Conclusion Botulinum toxin type A injection has good effects in the treatment of acute concomitant esotropia, with high safety and repeatability, and can be used as the first choice for the early treatment of acute concomitant esotropia. |
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