| 郭致飞,汪超,马春春,等.B淋巴细胞瘤 -2结合抗凋亡基因 1在人脑胶质瘤中的表达及临床意义[J].安徽医药,2022,26(10):1949-1953. |
| B淋巴细胞瘤 -2结合抗凋亡基因 1在人脑胶质瘤中的表达及临床意义 |
| Expression and clinical significance of anti-apoptotic gene BAG-1 in human glioma |
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| DOI：10.3969/j.issn.1009-6469.2022.10.010 |
| 中文关键词: 神经胶质瘤 抗凋亡基因 1 B淋巴细胞瘤 -2基因(bcl-2) 免疫组化 预后 |
| 英文关键词: Glioma BAG-1 B-cell lymphoma-2(bcl-2) Immunohistochemical Prognosis |
| 基金项目:安徽医科大学基础和临床合作研究提升计划项目( 2020xkjT044) |
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| 中文摘要: |
| 目的探讨 B淋巴细胞瘤 -2(B-cell lymphoma-2，Bcl-2)结合抗凋亡基因 1(Bcl-2-associated athanogene 1，BAG-1)在人脑胶质瘤中的表达及临床意义。方法应用免疫组织化 SP二步法，检测 2009年 9月至 2021年 9月年安徽医科大学第二附属医院的 212例人脑胶质瘤标本以及 10例正常脑组织标本中的 BAG-1的表达，分析其与临床病理及预后的关系。结果检测到 BAG-1总体的阳性表达率为 61.3％， BAG-1在低级别胶质瘤( Ⅰ~Ⅱ级)和高级别胶质瘤( Ⅲ~Ⅳ级)阳性表达率分别为 48.4%和 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of B-cell lymphoma-2-associated apoptosis gene 1 (BAG-1) in human glioma.Methods Immunohistochemical SP two-step method was used to detect BAG-1 expression in 212 human glioma tissues and 10 normal brain tissues obtained from Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medi.cal University from September 2009 to September 2021, and the relationship between BAG-1 expression and clinicopathology and prog. nosis was analyzed.Results The overall positive expression rate of BAG-1 was 61.3%, and the positive expression rates of BAG-1 in low-grade (Ⅰ-Ⅱ) and high-grade (Ⅲ-Ⅳ) gliomas were 48.4% and 71.1%, respectively (P=0.001). The median survival time of patients with negative and positive BAG-1 expression were 60 months and 17 months, respectively (P<0.001). The median survival time of nega. tive and positive BAG-1 expression in patients with high-grade gliomas were 31 months and 11 months, respectively (P<0.001). The me. dian progression-free survival time of patients with negative and positive BAG-1 expressions were 26 months and 8 months, respective. ly (P=0.001).Conclusions BAG-1 is highly expressed in human glioma, which is positively correlated with the pathological grading ofthe tumor and negatively correlated with the survival time. BAG-1 may be an important molecular marker to predict the prognosis of gli. oma and the efficacy of chemotherapy. |
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