| 饶敏,吴祥,卢中朝.分泌型卷曲相关蛋白 5、CXC趋化因子受体 4、8-异构前列腺素水平与支气管哮喘病儿气道炎症、气道重塑的关系[J].安徽医药,2022,26(11):2231-2236. |
| 分泌型卷曲相关蛋白 5、CXC趋化因子受体 4、8-异构前列腺素水平与支气管哮喘病儿气道炎症、气道重塑的关系 |
| Relationship between serum SFRP5, CXCR4, 8-iso PG levels and airway inflammation and airway remodeling in children with bronchial asthma |
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| DOI：10.3969/j.issn.1009-6469.2022.11.025 |
| 中文关键词: 哮喘 分泌型卷曲相关蛋白 5 CXC趋化因子受体 4 8-异构前列腺素 气道炎症 气道重塑 病情程度 |
| 英文关键词: Asthma SFRP5 CXCR4 8-iso PG Airway inflammation Airway remodeling Severity of illness |
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| 中文摘要: |
| 目的探究支气管哮喘病儿血清分泌型卷曲相关蛋白 5(SFRP5)、 CXC趋化因子受体 4(CXCR4)、 8-异构前列腺素( 8-iso PG)水平与气道炎症、气道重塑的关系及联合评估病情程度的价值。方法选取 2018年 1月至 2020年 8月攀枝花市中心医院收治的支气管哮喘病儿 113例作为研究对象，按照病情程度分为轻度组、中度组、重度组，比较三组一般资料、血清 SFRP5、CXCR4、8-iso PG水平、气道炎症指标［肿瘤坏死因子 -α(TNF-α)、可溶性人基质裂解素 2(sST2)、白细胞介素 -17(IL-17)］、气道重塑指标［痰液转化生长因子 β1(TGF-β1)、基质金属蛋白酶 9(MMP-9)、骨桥蛋白( OPN)］分析血清 SFRP5、CX. CR4、8-iso PG与气道炎症、气道重塑指标及病情程度的关系，评价血清 SFRP5、CXCR4、8-iso PG对病情程，度的评估价值。结 |
| 英文摘要: |
| Objective To explore the relationship between serum secreted frizzled-related protein 5 (SFRP5), CXC chemokine re. ceptor 4 (CXCR4), 8-isoprostane (8-iso PG) levels and airway inflammation and airway remodeling in children with bronchial asthma,and the value of joint assessment of disease severity.Methods A total of 113 children with bronchial asthma from January 2018 to Au.gust 2020 in Panzhihua Central Hospital were selected as the research objects, and they were assigned into mild group, moderate group,and severe group according to the severity of the disease. The general data, serum SFRP5, CXCR4, 8-iso PG levels, airway inflamma. tion indexes [tumor necrosis factor-α (TNF-α), soluble human stromal lysin 2 (sST2), interleukin-17 (IL-17)], airway remodeling indica. tors [sputum transforming growth factor β1 (TGF-β1), matrix metalloproteinase 9 (MMP-9), and osteopontin (OPN)] of the 3 groups were compared. The relationship between serum SFRP5, CXCR4, 8-iso PG and airway inflammation, airway remodeling indicators and dis.ease severity was analyzed, and the evaluation value of serum SFRP5, CXCR4, 8-iso PG on the disease severity was evaluated.Re. sults The scores of act, FEV1, PEF, FEV1/FVC: severe groupmoderate group>mild group (P<0.05). After adjusting theact score, FEV1, PEF, FEV1/FVC, airway inflammation, airway remodeling and other factors, serum Sfrp5, CXCR4, 8-iso PG were still significantly associated with the severity of bronchial asthma (P<0.05). ROC analysis showed that the AUC (95% CI) of serum Sfrp5, CXCR4, 8-iso PG and their combination in evaluating the severity of bronchial asthma in children were 0.72 (0.51,0.94), 0.81 (0.69,0.93), 0.75 (0.51,0.99) and 0.87 (0.83,0.92), respectively.Conclusion Serum SFRP5, CXCR4, 8-iso PG can affect the severity of thedisease by regulating airway inflammation and airway remodeling in bronchial asthma. The combined detection of the three levels is ex.pected to provide a new method for the evaluation of the disease. |
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