| 王攀,申庆文,叶国柳.血清 25羟维生素 D3、糖类抗原 125、睾酮在子宫内膜癌中的表达及其联合检测的临床价值[J].安徽医药,2022,26(12):2434-2438. |
| 血清 25羟维生素 D3、糖类抗原 125、睾酮在子宫内膜癌中的表达及其联合检测的临床价值 |
| Expression of serum 25(OH)D3, CA125 and testosterone in endometrial carcinoma and their combined clinical value |
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| DOI：10.3969/j.issn.1009-6469.2022.12.022 |
| 中文关键词: 子宫内膜肿瘤 骨化二醇 CA-125抗原 睾酮 癌症早期检测 |
| 英文关键词: Endometrial neoplasms Calcifediol CA-125 antigen Testosterone Early detection of cancer |
| 基金项目:安徽省教育厅高校自然研究项目( KJ2019A0343) |
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| 中文摘要: |
| 目的探讨女性血清 25羟维生素 D3［25(OH)D3］、糖类抗原 125(CA125)、睾酮在子宫内膜癌中的表达水平及其三项同时检测对子宫内膜癌诊断的临床价值研究。方法选择 2020年 10月至 2021年 4月蚌埠医学院第一附属医院住院并手术的子宫内膜癌 50例(均由该院病理科诊断为子宫内膜癌)、子宫良性病变 40例和同期在该院体检各方面均正常的健康人 30例。各组血清 25(OH)D3、CA125、睾酮的表达水平检测方法均为电化学发光法。结果血清 25(OH)D3在子宫内膜癌组中的表达水平为( 16.83±5.49)μg/L，在子宫良性病变组中的表达水平为( 18.52±5.92)μg/L，差异无统计学意义( P>0.05)，但血清 25(OH) D3在子宫内膜癌组中的表达水平( 16.83±5.49)μg/L和子宫良性病变组中的表达水平( 18.52±5.92)μg/L均低于健康组( 25.21±5.02)μg/L(P<0.05)。血清 CA125、睾酮在子宫内膜癌组中的表达水平均明显升高，且数值明显高于子宫良性病变组及健康组(P<0.05)。血清 25(OH)D3、CA125、睾酮表达水平与子宫内膜癌手术病理分期相关。随着 FIGO分期升高、病理分级、浸润肌层深度增加、有淋巴结转移的病人血清 25(OH)D3水平呈下降的趋势，血清 CA125水平则是逐渐增高，且结果显示有明显相关性( P<0.05)。血清睾酮表达水平与淋巴结是否转移、病理分级差异无统计学意义( P>0.05)，仅受 FIGO分期、肌层浸润的深度影响，随着 FIGO分期升高、肌层浸润深度增加，血清睾酮水平呈上升的趋势( P<0.05)。 25(OH)D3、CA125和睾酮三项同时检测对诊断子宫内膜癌的灵敏度为 98.0％，准确度为 76.0%，诊断指数 52.0%，均明显高于单独检测，且 P<0.05。结论子宫内膜癌组血清 25(OH)D3呈低水平表达，与疾病病理特征关系呈负相关；血清 CA125呈高水平表达，与疾病病理特征关系呈正相关；而血清睾酮仅受 FIGO分期、肌层浸润的深度影响，与淋巴结是否转移、病理分级无关。血清 25(OH)D3、CA125、睾酮多指标联合检测可提高子宫内膜癌诊断的灵敏度、诊断指数、准确度，对子宫内膜癌的早期筛查、疾病临床病理特征的分析有较好的临床指导意义。 |
| 英文摘要: |
| Objective To investigate the expression of female level of serum 25(OH)D3, carbohydrate protein CA125 (CA125) andtestosterone in patients with endometrial carcinoma, and their combined clinical application in endometrial carcinoma.Methods Data were collected in the First Affiliated Hospital of Bengbu Medical College from October 2020 to April 2021, and 50 patients with endo.metrial cancer (all diagnosed with endometrial cancer by the pathology department of the hospital), 40 patients with benign uterine le.sions and 30 healthy patients who were normal in all aspects of physical examination were selected. The expression levels of serum 25(OH) D3, CA125 and testosterone in each group were detected by electrochemiluminescence.Results The expression level of serum25 (OH) D3 in endometrial cancer group was (16.83±5.49)μg/L, and that in benign uterine lesions group was (18.52±5.92)μg/L. Therewas no significant difference (P>0.05) between the two groups. However, the expression level of serum 25 (OH) D3 in endometrial can.cer group (16.83±5.49) μg/L and benign uterine disease group (18.52±5.92) μg/L was lower than that in healthy group (25.21±5.02) μg/L.The difference was statistically significant (P<0.05).The expression levels of serum CA125 and testosterone in endometrial cancergroup were significantly increased, and the values were significantly higher than those in benign uterine lesions group and healthygroup, and the differences were statistically significant (P<0.05). The expression levels of serum 25 (OH) D3, CA125 and testosteronewere correlated with the pathological stage of endometrial carcinoma. With the increase of FIGO stage, pathological grade, depth of in. filtrating muscle layer and lymph node metastasis, serum 25 (OH) D3 level showed a downward trend, while serum CA125 level in.creased gradually, and the results showed a significant correlation (P<0.05).There was no significant difference in serum testosterone expression level with lymph node metastasis or pathological grade (P>0.05), but only affected by FIGO stage and depth of myometriuminvasion. With the increase of FIGO stage and depth of myometrium invasion, serum testosterone level showed an upward trend (P< 0.05).The sensitivity, accuracy and diagnostic index of the simultaneous detection of 25 (OH) D3, CA125 and testosterone in the diagno.sis of endometrial cancer were 98.0%, 76.0% and 52.0%, which were significantly higher than those of the single detection (P<0.05). Conclusions Serum 25(OH)D3 is low in endometrial cancer group, which is negatively correlated with pathological features of the dis.ease. Serum CA125 is highly expressed, which is positively correlated with pathological features of the disease. Serum testosterone isonly affected by FIGO stage and the depth of myometrial infiltration, but it is not associated with lymph node metastasis or pathologicalgrade. The combined detection of serum 25(OH)D3, CA125 and testosterone can improve the sensitivity, diagnostic index and accuracyof the diagnosis of endometrial cancer, and has a good clinical guiding significance for the screening of endometrial cancer, the analysisof the clinicopathological characteristics of the disease and the monitoring of the follow-up progress of the disease. |
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