| 艾尔哈提 ·胡赛因,赵亮,阿依甫汗 ·阿汗,等.原发性胆囊癌根治术预后生存影响因素分析[J].安徽医药,2024,28(4):705-709. |
| 原发性胆囊癌根治术预后生存影响因素分析 |
| Prognostic factors of primary gallbladder carcinoma after radical cholecystectomy |
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| DOI：10.3969/j.issn.1009-6469.2024.04.014 |
| 中文关键词: 胆囊肿瘤 胆囊切除术 预后 胆囊癌 T分期 胆囊癌 N分期 |
| 英文关键词: Gallbladder neoplasms Cholecystectomy Prognostic T stage of gallbladder cancer N stage of gallbladder cancer |
| 基金项目:省部共建国家重点实验室开放课题( SKL-HIDCA-2019-17) |
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| 中文摘要: |
| 目的探讨胆囊癌根治术的临床疗效及预后影响因素。方法收集在 2013年 1月至 2021年 1月就诊于新疆医科大学第一附属医院 105例实施胆囊癌根治术病人的临床及病理资料。分别采用寿命表法和 Kaplan-Meier法计算总体和各组的中位生存时间和生存率，多因素分析采用 Cox比例回归风险模型。结果 105例病人中位生存时间为 26.49个月， 1年、 2年、 3年累计生存率分别为 69.29%、53.50%、39.64%。单因素分析结果显示:年龄、腹痛、分化程度、 T期、 N期、出血量、总胆红素、 CA199、癌胚抗原等指标是胆囊癌根治术预后危险因素，组间生存率差异有统计学意义( P<0.05)。Cox回归分析结果显示腹痛、分化程度、 T分期、 N分期等指标与病人预后有关( P<0.05)对应 HR 95%CI值分别为 2.97(1.41，6.23)、 4.56(1.49，13.93)、 4.92(1.55，14.30)、2.94(1.29，6.68)、 3.37(1.48，7.66)、 4.55(2.33.89)。结论腹痛、分化程度、 T分期、 N分期等指标是胆囊癌根治术预后，8，的独立危险因素。准确分期、早期干预可有助于改善预后。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy and prognostic factors of radical cholecystectomy for primary gallbladder cancer.Methods The clinical and pathological data of 105 patients who had undergone radical cholecystectomy in the First AffiliatedHospital of Xinjiang Medical University from January 2013 to January 2021 were collected retrospectively. The median survival timeand survival rate of overall population and each group were calculated by life table method and Kaplan Meier method, while Cox propor?tional hazard regression model was used for multivariate analysis.Results The median survival time of the 105 patients was 26.49 months, and the 1-,2-and 3-year cumulative survival rates were 69.29%, 53.50% and 39.64%, respectively. The univariate analysis re?vealed that age, abdominal pain, degree of differentiation, T stage, N stage, amount of bleeding, total bilirubin, CA199 and carcinoem?bryonic antigen were the prognostic risk factors of radical cholecystectomy. Cox regression analysis showed that abdominal pain, degreeof differentiation, T stage and N stage were related to the prognosis of patients (P < 0.05). The corresponding HR values and 95%CI val? ues of these indexes were 2.97 (1.41, 6.23), 4.56 (1.49, 13.93), 4.92 (1.55, 14.30), 2.94 (1.29, 6.68) and 3.37 (1.48, 7.66), 4.55 (2.33,8.89), respectively.Conclusion Abdominal pain, degree of differentiation, T stage and N stage are independent risk factors for GBCpatient's survivor after radical cholecystectomy. Accurate staging and early intervention can improve the prognosis patients. |
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