文章摘要
张娟.肝豆状核变性中医证型与统一Wilson病评定量表相关性分析[J].安徽医药,待发表.
肝豆状核变性中医证型与统一Wilson病评定量表相关性分析
投稿时间:2019-07-30  录用日期:2019-08-16
DOI:
中文关键词: 肝豆状核变性 Wilson病评定量表 中医证型 相关性
英文关键词: 
基金项目:国家自然科学基金面上项目(No.81774299);安徽省自然科学基金面上项目(No.170805MH199)
作者单位E-mail
张娟 安徽中医药大学第一附属医院 1477210980@qq.com 
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中文摘要:
      目的:探讨肝豆状核变性(Wilson disease, WD)患者中医证型与统一Wilson病评定量表相关性。方法:纳入2016年08月至2018年9月在安徽中医药大学第一附属医院住院的肝豆状核变性患者80例,对其进行中医证候辨证分型,进行统一Wilson病评定量表评分。采用方差分析、二元Logistic 回归分析探讨不同中医证型WD与统一Wilson病评定量表评分的相关性。结果:80例患者中,痰瘀互结证是最为常见的中医证型,其次为湿热内蕴证。痰瘀互结证的神经功能评分高于脾肾阳虚证,且低于肝气郁结证的神经功能评分,差异有明显统计学意义;肝气郁结证的神经功能评分明显高于脾肾阳虚证,差异有明显统计学意义;湿热内蕴证及脾肾阳虚证的肝脏功能评分均高于痰瘀互结证,差异均有明显统计学意义;肝气郁结证精神症状评分高于痰瘀互结证、湿热内蕴证及脾肾阳虚证,差异均有明显统计学意义。神经功能评与痰瘀互结证分呈正相关(OR=1.767,P<0.05)而与脾肾阳虚证呈负相关(OR=0.849,P<0.05),湿热内蕴证、脾肾阳虚证与肝脏功能评分呈正相关(OR=1.384,P<0.05,R=2.976,P<0.05),而与痰瘀互结证呈负相关(OR=0.516,P<0.05),精神症状评分与肝气郁结证呈正相关(OR=3.128,P<0.05)。结论:Wilson病不同中医证型之间的统一Wilson病评定量表各功能评分具有一定的差异性,并且不同中医证型与统一Wilson病评定量表各功能评分具有一定相关性。
英文摘要:
      Abstract objective: To investigate the correlation between the TCM syndromes and Unified Wilson's Disease Rating Scale in Wilson disease (WD) patients. Methods: A total of 80 patients of WD patients in the First Affiliated hospital of Anhui University of Chinese Medicine from August 2016 to September 2018 were included, and their TCM syndromes and syndromes were classified into different types, to score the Unified Wilson Disease Rating Scale .Using Variance Analysis and binary Logistic regression Analysis to explore the correlation between the TCM syndromes and Unified Wilson's Disease Rating Scale in WD patients. Results: Among the 80 patients,phlegm-stasis syndrome was the most common TCM syndrome, followed by dampness-heat syndrome.The score of nerve function in the syndrome of phlegm-stasis was higher than that in the syndrome of Pi-Shen yang deficiency, and lower than that in the syndrome of liver-qi stasis, the difference was statistically significant. The neurological function score of liver-qi stasis syndrome was significantly higher than that of Pi-Shen yang deficiency syndrome, and the difference was statistically significant. The liver function scores of damp-heat syndrome and Pi-Shen yang deficiency syndrome were higher than those of phlegm-stasis syndrome, and the differences were statistically significant. The scores of mental symptoms of liver-qi stasis syndrome were higher than those of phlegm-stasis syndrome, damp-heat syndrome and Pi-Shen yang deficiency syndromet. Neurological function score was positively correlated with syndrome of phlegm-stasis (OR=1.767,P<0.05) and negatively correlated with syndrome of Pi-Shen yang deficiency (OR=0.849,P<0.05). Liver function score was positively correlated with syndrome of damp-heat and Pi-Shen yang deficiency(OR=1.384,P<0.05, R=2.976,P<0.05), and negatively correlated with syndrome of phlegm-stasis (OR=0.516,P<0.05).And mental symptoms score was positively correlated with syndrome of liver-qi stasis (OR=3.128,P<0.05).Conclusion: There are certain differences between the TCM syndrome types and the functional scores of the Unified Wilson's Disease Rating Scale of Wilson disease, and there are also a certain correlation between that.
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